Results 111 to 120 of about 913,703 (307)

130 Characterizing ocular adverse events in clinical trials of GLP-1 drugs using weighted and unweighted participant counts results reported on ClinicalTrials.gov

Journal of Clinical and Translational Science
Objectives/Goals: Ocular adverse events (OAEs) have been associated with GLP-1 use in clinical studies. This study aims to describe the proportion and distribution of ocular adverse events by treatment arm, including serious and non-serious events, in ...
Roberta Bruhn, Katie Steimel, Christina Barone   +2 more
doaj   +1 more source

Efficacy of platelet-rich plasma as conservative treatment in orthopaedics. a systematic review and meta-analysis [PDF]

, 2018
Background. The aim of this systematic review and meta-analysis was to evaluate the benefit of platelet-rich plasma (PRP) in non-surgical orthopaedic procedures. Material and methods. We searched the Cochrane Wounds Specialized Register, CENTRAL, MEDLINE
Cruciani, Mario, Franchini, Massimo, Liumbruno, Giancarlo M, Marano, Giuseppe, Masiello, Francesca, Mengoli, Carlo, Pati, Ilaria, Pupella, Simonetta, Vaglio, Stefania, Veropalumbo, Eva   +9 more
core   +1 more source

Enhanced Endoscopic Internal Drainage of Gastric Abscess Through Additively Manufactured Stents

Advanced Healthcare Materials, EarlyView.
Postoperative gastric leaks are often treated with off‐label biliary double‐pigtail stents, yet conventional extruded designs are not optimized for leak anatomy, can migrate, and may limit abscess evacuation. PETALS is introduced to optimize transmural drainage geometry and enable patient‐specific 3D‐printable stents.
Parima Phowarasoontorn, Yongbin Ko, Juan S. Barajas‐Gamboa, Juan P. Pantoja, Oraib Al‐Ketan, Mohamed Ali, Sungyun Sohn, Heba Tageldeen Naser, Abdel‐Hameed Dabbour, Batoul Khlaifat, Ahmed AlZubaidi, Carlos Abril Vega, John Rodriguez, Matthew Kroh, Khalil B. Ramadi   +14 more
wiley   +1 more source

131 Using clinical trials transformation initiative AACT database to assess adverse events in clinical trials of GLP-1 drugs

Journal of Clinical and Translational Science
Objectives/Goals: The study aims to systematically characterize the frequency and distribution of serious and non-serious adverse events by intervention arm and organ system in clinical trials of GLP-1 drugs using the publicly available Aggregate Content
Katie Steimel, Jesse Reynolds, Christina Barone, Roberta Bruhn   +3 more
doaj   +1 more source

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]

, 2014
BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Andersen, Peter, Bang, Peter, Beattie, Trevor, Churchyard, Gavin J., Daubenberger, Claudia, Fielding, Katherine L., Gardiner, Nicolene, Hanekom, Willem A., Hoff, Søren T., Hughes, Elisabeth J., Jeffery, Hannah, Kagina, Benjamin M., Katsoulis, Lynn, Kromann, Ingrid, Landay, Alan, Lenz, Nicole, Mfinanga, Elirehema, Pohl, Christian, Reither, Klaus, Said, Khadija, Scriba, Thomas J.   +20 more
core   +5 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis [PDF]

, 2012
BACKGROUND: Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all global cases of MDR tuberculosis. Clinical management is especially challenging, and recommendations are
Abubakar, Al-Dabbagh, Borenstien, Caminero, Dena Ettehad, Drobac, du Cros, Fairlie, Falzon, Feja, Furin, Furin, Golder, Graham S Cooke, Granich, Guyatt, H Simon Schaaf, Hesseling, Hesseling, Houwert, James A Seddon, Johnston, Laserson, Leung, Mendez Echevarria, Mitnick, Munsiff, Nathan Ford, Nelson, Newcombe, Nicol, Orenstein, Padayatchi, Riley, Rucker, Schaaf, Schaaf, Schaaf, Schaaf, Schaaf, Seddon, Smith, Swanson   +42 more
core   +2 more sources

Analysis of serious adverse event: Writing a narrative

Perspectives in Clinical Research, 2018
One of the reasons that a research molecule undergoes through different phases of clinical trials is to establish the safety and efficacy of the drug. To establish the safety profile of any drug, the most important aspect is to evaluate every adverse event (AE) that a clinical trial individual experiences. This detail is provided by any investigator or
openaire   +3 more sources

Vat Polymerization 3D Printing for Controlled Drug Release Applications

Advanced Materials Technologies, EarlyView.
ABSTRACT Vat polymerization (VP) 3D printing, a light‐based additive manufacturing technique, has emerged as a promising technique for fabricating complex drug delivery systems with high precision and spatial resolution. This layer‐by‐layer manufacturing process enables the creation of intricate geometries and customizable architectures, which are ...
Hafiz Busari, O. Thompson Mefford, M. Aaron Vaughn   +2 more
wiley   +1 more source

A comprehensive analysis on the safety of two biologics dupilumab and omalizumab

Frontiers in Medicine
Dupilumab was approved for the treatment of several dermatologic immune-mediated inflammatory diseases, such as atopic dermatitis and bullous pemphigoid; whereas omalizumab is the first biological agent which was approved to treat chronic spontaneous ...
Yu Xiao, Wanying Yang, Muyang Wang
doaj   +1 more source