Results 31 to 40 of about 913,703 (307)

Serious adverse events after cataract surgery [PDF]

Current Opinion in Ophthalmology, 2012
Over the past several decades, there have been many advances in the equipment, instrumentation and techniques of performing cataract surgery. This review will address the impact of these advances on the safety profile of cataract surgery.Recent studies have demonstrated a decline in the risk of serious postoperative adverse events (endophthalmitis ...
openaire   +2 more sources

Safety aspects of infliximab in inflammatory bowel disease patients - A retrospective cohort study in 100 patients of a German University Hospital [PDF]

, 2004
Background: Infliximab, a chimeric anti-tumour necrosis factor monoclonal antibody with potent anti-inflammatory effects, represents an effective treatment option in patients with severe inflammatory bowel disease (IBD).
Ali Y, Baker D, Burkhard Göke, Cohen RD, Hanauer S, Hommes DW, Jani AL, Julia Seiderer, Puchner TC, Sample C, Sandborn WJ, Thomas Ochsenkühn   +11 more
core   +1 more source

Oral herbal therapies for treating osteoarthritis (review) [PDF]

, 2014
Background Medicinal plant products are used orally for treating osteoarthritis. Although their mechanisms of action have not yet been elucidated in full detail, interactions with common inflammatory mediators provide a rationale for using them to ...
Cameron, Melainie, Chrubasik, Sigrun
core   +1 more source

Differing severities of acute exacerbations of idiopathic pulmonary fibrosis (IPF): insights from the INPULSIS® trials

Respiratory Research, 2019
Background Given the broad definition of an acute exacerbation of IPF, it is likely that acute exacerbations are heterogeneous in their aetiology, severity and clinical course. We used pooled data from the INPULSIS® trials of nintedanib versus placebo to
Michael Kreuter, Harald Koegler, Matthias Trampisch, Silke Geier, Luca Richeldi   +4 more
doaj   +1 more source

Safety and efficacy of a propofol and ketamine based procedural sedation protocol in children with cerebral palsy undergoing botulinum toxin A injections. [PDF]

, 2019
Background Pediatric patients with cerebral palsy (CP) often undergo intramuscular botulinum toxin (BoNT‐A) injections. These injections can be painful and may require procedural sedation.
Abu-Sultaneh, Samer, Abulebda, Kamal, Louer, Ryan, Lutfi, Riad, McKinney, Renee C.   +4 more
core   +1 more source

Assessing the risk-benefit profile of ramucirumab in patients with advanced solid tumors: A meta-analysis of randomized controlled trials

EClinicalMedicine, 2020
Background: Ramucirumab is a widely used cancer drug having gained six regulatory approvals in various advanced solid tumors. Thus, assessing the risk-benefit profile of such a commonly used drug across multiple tumor types is necessary to inform ...
Sophie Marie Anne Effing, Bishal Gyawali
doaj   +1 more source

Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients [PDF]

, 2016
Aims: We aimed to conduct a meta-analysis of serious adverse events (macro- and micro-vascular events, falls and fractures, death) associated with hypoglycaemia in older patients.
Bloomfield, Bonds, Caverly, Chiba, Duckworth, Frier, Goto, Hamada, Hsu, Johnston, Johnston, Kachroo, Katharina Mattishent, Khunti, Leal, Majumdar, Mattishent, Mccoy, Office of Public and Intergovernmental Affairs, Origin Trial Investigators, Rajpathak, Rathmann, Schwartz, Signorovitch, Sinclair, Thapa, Wright, Yoon Kong Loke, Yun, Zhao, Zhao, Zoungas   +31 more
core   +1 more source

Serious adverse events in academic critical care research [PDF]

Canadian Medical Association Journal, 2008
Although it might be ideal to have a single system for defining and reporting serious adverse events that would be applicable to both academic trials investigating established drugs and industry-sponsored trials of novel pharmaceutical agents, such a system would be unlikely to satisfy ...
Deborah, Cook, François, Lauzier, Marcelo G, Rocha, Mary Jane, Sayles, Simon, Finfer   +4 more
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Reporting of harms outcomes: a comparison of journal publications with unpublished clinical study reports of orlistat trials [PDF]

, 2016
Background The quality of harms reporting in journal publications is often poor, which can impede the risk-benefit interpretation of a clinical trial. Clinical study reports can provide more reliable, complete, and informative data on harms compared to ...
Hodkinson, Alex
core   +1 more source

Incidence of Serious Adverse Events During Nocturnal Polysomnography [PDF]

Sleep, 2004
The purpose of the study was to verify whether minimal concern is warranted in regard to serious adverse effects in the sleep laboratory.A prospective multicenter studyThree scoring teams for 17 sleep laboratories.Reports of adverse events occurring during polysomnography or identified upon scoring a study were collected over an 18-month time period ...
Reena, Mehra, Kingman P, Strohl
openaire   +2 more sources