Results 241 to 250 of about 2,900,618 (308)

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

open access: yesiNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang   +13 more
wiley   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

open access: yesInterdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li   +15 more
wiley   +1 more source

Preliminary Development and Assessment of a Multiplex Assay for Human Papillomavirus Antibody Detection Using Commercial L1 Proteins

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study developed and assessed a new multiplex assay for the simultaneous detection of antibodies against multiple Human Papillomavirus (HPV) types. Using recombinant L1 protein, the assay quantifies IgG and IgA responses in human plasma, enabling comprehensive immune profiling across multiple high‐risk cancer‐associated HPV genotypes. This approach
Arash Aslanabadi   +11 more
wiley   +1 more source

Improved Case Detection of Fleaborne Typhus by PCR Testing, Los Angeles County, California, USA, 2022-2024. [PDF]

open access: yesEmerg Infect Dis
Sanosyan A   +10 more
europepmc   +1 more source

The Patient With Multiple Alloantibodies: A Systematic Strategy for Antibody Identification and Transfusion Management. [PDF]

open access: yesCase Reports Immunol
Alharbi A   +18 more
europepmc   +1 more source

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