Results 1 to 10 of about 2,869 (208)

Liposomes: from August Wassermann to Vaccines Against COVID-19 [PDF]

ADMET and DMPK, 2023
Background and Purpose: The development of vaccines against the SARS-CoV-2 virus has become a big challenge for many countries in 2020-2022. mRNA vaccines were shown to be effective and safe and have been widely used worldwide in the fight against the ...
Ganna Grygorieva, Daria Pylypenko, Yuriy Krasnopolsky   +2 more
doaj   +6 more sources

A multi-country comparative study of two treponemal tests for the serodiagnosis of syphilis amongst men who have sex with men (MSM): Chemo-luminescent assay vs Treponema pallidum particle agglutination assay [PDF]

BMC Infectious Diseases
Introduction International guidelines recommend routine screening for syphilis (aetiological agent: Treponema pallidum subspecies pallidum) amongst key populations and vulnerable populations using tests detecting treponemal and non-treponemal antibodies.
Lorenzo Gios, Massimo Mirandola, Maddalena Cordioli, Antonella Zorzi, Nigel Sherriff, Jaime Vera, Dominika Wlazly, Mohammed Osman Hassan-Ibrahim, Valeska Padovese, Anabel Darmanin, Rosanna W. Peeling, Magnus Unemo, Karel Blondeel, Igor Toskin   +13 more
doaj   +5 more sources

Syphilis in pregnancy: A practical guide for prenatal care providers. [PDF]

Int J Gynaecol Obstet
Abstract Syphilis during pregnancy remains a persistent global public health challenge. Untreated or inadequately treated syphilis infection during pregnancy contributes significantly to preventable perinatal morbidity and mortality. In the last five years, a resurgence of syphilis among pregnant women in several regions has led to a concerning rise in
Desjardins AA, Amaral E, Miranda J, Pasupathy D, Martins ML, Buga E, Aronoff D, Money D, Boucoiran I, FIGO Committee on Infections During Pregnancy and FIGO Committee on Health Systems Strengthening.   +9 more
europepmc   +2 more sources

The tradition algorithm approach underestimates the prevalence of serodiagnosis of syphilis in HIV-infected individuals. [PDF]

PLoS Neglected Tropical Diseases, 2017
Currently, there are three algorithms for screening of syphilis: traditional algorithm, reverse algorithm and European Centre for Disease Prevention and Control (ECDC) algorithm. To date, there is not a generally recognized diagnostic algorithm.
Bin Chen, Xiuming Peng, Tiansheng Xie, Changzhong Jin, Fumin Liu, Nanping Wu   +5 more
doaj   +3 more sources

Acquired syphilis: update on clinical, diagnostic and therapeutic aspects [PDF]

Anais Brasileiros de Dermatologia
Syphilis, an infection caused by Treponema pallidum, transmitted predominantly through sexual contact, affects several organs, causing skin, mucous membranes and systemic lesions.
Carolina Talhari, Kaique Arriel, Marcio Soares Serra, John Verrinder Veasey   +3 more
doaj   +2 more sources

The difficulties of diagnosis of neurosyphilis at the modern stage

Лечащий Врач, 2021
At the modern stage in Russia, we can observe the tendency of increase in recording cases of neurosyphilis against the background of reduction of morbidity rate of syphilitic infection in general.
T. L. Vizilo, T. V. Poponnikova, I. F. Fedoseeva, E. D. Vasenina   +3 more
doaj   +1 more source

Assessment of recombinant antigens Tp0100 and Tp1016 of Treponema pallidum for serological diagnosis of syphilis

Journal of Clinical Laboratory Analysis, Volume 36, Issue 9, September 2022., 2022
SDS‐PAGE analysis of the expression and purification of recombinant proteins. (A, B) Tp0100 (22 kDa); (C, D) Tp1016 (39 kDa). M: molecular mass markers; N:noninduced; I: induced with IPTG; P: purification. Western blotting identification of recombinant proteins Tp0100 and Tp1016 with sera from normal rabbits (1), sera from uninfected human (2), anti ...
Dejun Chen, Siqian Wang, Yuxing He, Yue Fu, Feijun Zhao, Xiuping Zhou, Haoquan Yin, Jia Wan, Yunting Huang, Yimou Wu, Longgu Cao, Tiebing Zeng   +11 more
wiley   +1 more source

Improved Performance of ELISA and Immunochromatographic Tests Using a New Chimeric A2‐Based Protein for Human Visceral Leishmaniasis Diagnosis

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
Summary. Human visceral leishmaniasis (VL) is a major public health problem worldwide, leading to significant mortality rates if not properly treated and controlled. Precise identification of infected patients is essential to establish treatment and control measures.
Maria Marta Figueiredo, Anna R. R. dos Santos, Lara C. Godoi, Natália S. de Castro, Bruno C. de Andrade, Sarah A. R. Sergio, Selma M. B. Jerônimo, Edward J. de Oliveira, Ruth T. Valencia-Portillo, Lucilândia M. Bezerra, Hiro Goto, Maria C. A. Sanchez, Caroline Junqueira, Santuza M. R. Teixeira, Flávio G. da Fonseca, Ricardo T. Gazzinelli, Ana Paula Fernandes, Gabriela Santos-Gomes   +17 more
wiley   +1 more source

The Clinical Characteristics and Serological Outcomes of Infants With Confirmed or Suspected Congenital Syphilis in Shanghai, China: A Hospital-Based Study

Frontiers in Pediatrics, 2022
BackgroundCongenital syphilis (CS) is the infection of an infant or fetus with Treponema pallidum. The aim of this study was to investigate the clinical features and outcomes of serology reversion in infants diagnosed with confirmed or suspected ...
Yi Dai, Guanpeng Zhai, Shulian Zhang, Chao Chen, Zhihua Li, Wenjing Shi, Wenjing Shi   +6 more
doaj   +1 more source

Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.

PLoS ONE, 2022
ObjectivesWe investigated people with HIV (PWH) receiving combination antiretroviral therapy (cART) for latent syphilis infection prevalence, risk factors, treatment response, and neurosyphilis.MethodsA prospective follow-up study was conducted on PWH ...
Selamawit Girma, Wondwossen Amogne
doaj   +1 more source