Results 31 to 40 of about 57,279 (308)
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Background and Objectives: SARS-CoV-2 is a newly discovered viral infection. It’s still unclear how antibodies react in infected individuals, and there is not enough evidence to support the clinical use of antibody examination.
Kiana Shirani +6 more
doaj +1 more source
Estimating force of infection from serologic surveys with imperfect tests.
BackgroundThe force of infection, or the rate at which susceptible individuals become infected, is an important public health measure for assessing the extent of outbreaks and the impact of control programs.Methods and findingsWe present Bayesian methods
Neal Alexander +2 more
doaj +1 more source
Appropriate Serological Testing in Pregnancy [PDF]
We read with interest the recent report by Garner et al. [l], in which anti-E was detected early in pregnancy solely through the use of enzymetreated red blood cells (RBC). The serological reactivity of this anti-E changed dramatically during pregnancy; the antibody became detectable by the indirect antiglobulin test, and at 37 weeks’ gestation had a ...
Judd, W. John +2 more
openaire +3 more sources
Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of histologic features and treatment response.
Andrea Fava +48 more
wiley +1 more source
Objective We evaluated the role of 25‐hydroxyvitamin D (25[OH]D), prednisone, and other risk factors for bone mineral density (BMD) loss and osteoporosis in systemic lupus erythematosus (SLE). Methods We calculated the association between 25(OH)D levels and other potential risk factors and BMD measures (spine T scores) and osteoporosis (defined as a T ...
Nima Madanchi +4 more
wiley +1 more source
Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies.
Marie K. Das +5 more
doaj +1 more source
Laboratory perspectives for Leprosy: Diagnostic, prognostic and predictive tools
The diagnosis of leprosy poses several challenges. The bacillary load, serology, and tissue response are determined by the host immune status, which make individual tests unsuitable across the spectrum.
Kiran Preet Malhotra, Nuzhat Husain
doaj +1 more source
Serologic Testing for Celiac Disease [PDF]
We read with interest the report by Martini et al. (1). The authors compared the accuracy of five commercially available IgA anti-tissue transglutaminase (anti-tTG) ELISAs with data from anti-endomysial antibodies (EmAs) in the diagnosis and follow-up of adult patients with celiac disease (CD) and supported the superiority of the EmA test over ELISAs ...
BASSO D +2 more
openaire +2 more sources
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source

