Results 51 to 60 of about 83,632 (216)

Systemic Immunosuppression to Reduce Surgical Intervention in ANCA‐Negative Subglottic Stenosis

The Laryngoscope, EarlyView.
Idiopathic subglottic stenosis (iSGS) typically follows an indolent course managed with surgical dilatation, though a subset demonstrates aggressive, recurrent disease. In this retrospective cohort study, systemic immunosuppression significantly prolonged inter‐dilation intervals in both granulomatosis with polyangiitis‐associated SGS and an “atypical”
Guy Benshetrit, Stephen McAdoo, Romana Kuchai, Charles Pusey, Guri Sandhu, Chadwan Al‐Yaghchi   +5 more
wiley   +1 more source

Chimeric Antigen Receptor T‐Cells in Myasthenia Gravis: Advances, Safety Challenges, and Future Directions

Muscle &Nerve, EarlyView.
ABSTRACT This review examines the emerging application of chimeric antigen receptor (CAR) T‐cell therapy in myasthenia gravis (MG), with emphasis on safety, efficacy signals, and future therapeutic potential in treatment‐refractory disease. A comprehensive literature search was conducted across PubMed, medRxiv, bioRxiv, and Google Scholar for studies ...
Tobias Hegelmaier, Alexander Duscha, Christiane Desel, Sarah Stassen, Tim Krzemien, Ann‐Katrin Hennemann, Vaia Pappa, Aiden Haghikia   +7 more
wiley   +1 more source

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source

Fast Quantitative Evaluation of the Amelioration Effect in MASLD During Semaglutide Treatment Using Ultrasound‐Derived Fat Fraction and Fat‐to‐Muscle Ratio

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a chronic liver disease. Research into a feasible, rapid, and effective assessment method is crucial for evaluating the therapeutic effects of semaglutide in MASLD. This prospective study utilized ultrasound‐derived fat fraction measurement and fat‐to‐muscle ratio to evaluate hepatic ...
Yunlin Huang, Ruping Yang, Ying Wang, Xiu‐Yun Lu, Li Wei, Rui Cheng, Juan Cheng, Yijie Qiu, Shiwen Wang, Bo Li, Yi Dong   +10 more
wiley   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

Rheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning, Ruiling Feng, Kai Zhang, Yipeng Han, Ruoyi Wang, Guangwen Li, Yuebo Jin, Jing He   +7 more
wiley   +1 more source

A1vB Genotype With Weak A Antigen Expression: Resolution of an ABO Discrepancy Using Serological and Molecular Approaches

The Kaohsiung Journal of Medical Sciences, EarlyView.
Wan‐Hua Yang, Fen‐Cing Liou
wiley   +1 more source

Shape‐Memory Collagen/Silk‐Fibroin Scaffold for Dura Sealing and Skull Base Regeneration

Small, EarlyView.
ABSTRACT When a skull base defect occurs, reconstruction is typically performed using a variety of autologous grafts, flaps, or synthetic materials. Failure to achieve appropriate management and closure can lead to serious consequences, such as cerebrospinal fluid (CSF) leakage and subsequent meningitis.
SooJung Chae, Donghyeok Kim, Dongyun Kim, JaeYoon Lee, Sang Duk Hong, GeunHyung Kim   +5 more
wiley   +1 more source

Detection of Leptospira in cane toads (Rhinella jimi) from urban and rural Paraíba, Brazil

Veterinary Record, EarlyView.
Abstract Background Leptospirosis is a significant zoonosis in tropical regions, where poor sanitation and favourable climate aid its spread. Synanthropic animals such as the cane toad (Rhinella jimi), which share environments with both people and wild and domestic animals, may harbour Leptospira and contribute to urban and rural transmission cycles ...
Karla N. de Souza Rocha, Aline de Lima Peixoto, Lucila S. de Medeiros Pereira, Debora Ferreira Cardoso, Maria L. C. Rodrigues Silva, Sérgio S. de Azevedo, Juliana P. F. de Oliveira, Clebert J. Alves, Mozar Alves Fonseca, Severino S. dos Santos Higino   +9 more
wiley   +1 more source