Results 11 to 20 of about 67,859 (248)

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Spanish HCMV Seroprevalence in the 21st Century

Viruses, 2023
Human cytomegalovirus (HCMV) is linked to age-related diseases like cardiovascular disease, neurodegenerative conditions, and cancer. It can also cause congenital defects and severe illness in immunocompromised individuals.
Pablo Álvarez-Heredia, Irene Reina-Alfonso, José Joaquín Domínguez-del-Castillo, Fakhri Hassouneh, Carmen Gutiérrez-González, Alexander Batista-Duharte, Ana-Belén Pérez, Fernando Sarramea, María José Jaén-Moreno, Cristina Camacho-Rodríguez, Raquel Tarazona, Rafael Solana, Juan Molina, Alejandra Pera   +13 more
doaj   +1 more source

A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development

BMC Public Health, 2022
Cytomegalovirus (CMV) is a common pathogen that affects individuals of all ages and establishes lifelong latency. Although CMV is typically asymptomatic in healthy individuals, infection during pregnancy or in immunocompromised individuals can cause ...
K. Fowler, Jacek Mucha, M. Neumann, W. Lewandowski, M. Kaczanowska, M. Grys, Elvira Schmidt, A. Natenshon, C. Talarico, P. Buck, John Diaz-Decaro   +10 more
semanticscholar   +1 more source

WormWatch: Park soil surveillance reveals extensive Toxocara contamination across the UK and Ireland

Veterinary Record, Volume 192, Issue 1, 7/14 January 2023., 2023
Abstract Background Toxocarosis is a globally distributed zoonotic disease, but sources of infection are not well documented over large geographical scales. To determine levels of environmental contamination, soil from 142 parks and recreational areas across the UK and Ireland was assessed for the presence of Toxocara.
Paul M. Airs, Claire Brown, Erica Gardiner, Liz Maciag, Jamie P. Adams, Eric R. Morgan   +5 more
wiley   +1 more source

COVID-19 antibody seroprevalence in Santa Clara County, California

medRxiv, 2020
Background Addressing COVID-19 is a pressing health and social concern. To date, many epidemic projections and policies addressing COVID-19 have been designed without seroprevalence data to inform epidemic parameters.
E. Bendavid, Bianca Mulaney, N. Sood, Soleil Shah, Emilia J Ling, Rebecca Bromley-Dulfano, Cara Lai, Zoe Weissberg, Rodrigo Saavedra-Walker, J. Tedrow, Dona Tversky, Andrew Bogan, T. Kupiec, D. Eichner, Ribhav Gupta, J. Ioannidis, J. Bhattacharya   +16 more
semanticscholar   +1 more source

No evidence for yaws infection in a small‐scale cross‐sectional serosurvey in Ghanaian monkeys

Veterinary Medicine and Science, Volume 9, Issue 1, Page 507-512, January 2023., 2023
Our small‐scale cross‐sectional study found no antibodies against the yaws bacterium in Ghanian monkeys, such as the Monas monkey (Cercopithecus mona) shown in the picture. Nonhuman primate (NHP) testing in Ghana should be continued to reach a geographically equally distributed and species‐specific sample size that allows better statistical support to ...
Eugene Adade, Christian Roos, Idrissa Shomari Chuma, Augustina Angelina Sylverken, Sascha Knauf   +4 more
wiley   +1 more source

SARS-CoV-2 seroprevalence in children, parents and school personnel from June 2020 to April 2021: cohort study of 55 schools in Switzerland

Swiss Medical Weekly, 2022
BACKGROUND: Few studies have directly examined the incidence or seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in children, parents and teachers from the same school communities.
Agne Ulyte, Sarah R. Haile, Jacob Blankenberger, Thomas Radtke, Milo A. Puhan, Susi Kriemler   +5 more
doaj   +1 more source

Seroprevalence of Human Malawi Polyomavirus [PDF]

Journal of Clinical Microbiology, 2014
ABSTRACT The seroprevalence of the recently discovered human Malawi polyomavirus (MWPyV) was determined by virus-like particle-based enzyme-linked immunosorbent assay (ELISA) in age-stratified Italian subjects. The findings indicated that MWPyV infection occurs early in life, and seroprevalence was shown to reach 42% in adulthood.
Pierre Coursaget, Elisa Mazzoni, Giovanni Guerra, Jérôme T. J. Nicol, Jérôme T. J. Nicol, Valérie Leblond, Valérie Leblond, Mauro Tognon, Françoise Arnold, Françoise Arnold, Antoine Touzé, Antoine Touzé   +11 more
openaire   +5 more sources

Confidence Intervals for Seroprevalence

Statistical Science, 2022
This paper concerns the construction of confidence intervals in standard seroprevalence surveys. In particular, we discuss methods for constructing confidence intervals for the proportion of individuals in a population infected with a disease using a sample of antibody test results and measurements of the test's false positive and false negative rates.
DiCiccio, Thomas J., Ritzwoller, David M., Romano, Joseph P., Shaikh, Azeem M.   +3 more
openaire   +2 more sources

Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020.

JAMA Internal Medicine, 2020
Importance Reported cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection likely underestimate the prevalence of infection in affected communities. Large-scale seroprevalence studies provide better estimates of the proportion of
Fiona P Havers, Carrie Reed, Travis Lim, Joel M Montgomery, J. Klena, Aron J. Hall, Alicia M. Fry, Deborah L. Cannon, Cheng-Feng Chiang, Aridth Gibbons, Inna Krapiunaya, M. Morales-Betoulle, Katherine M Roguski, M. Rasheed, Brandi Freeman, S. Lester, Lisa Mills, Darin S. Carroll, S. M. Owen, Jeffrey A. Johnson, V. Semenova, Carina Blackmore, Debra Blog, S. Chai, Angela Dunn, Julie Hand, Seema Jain, S. Lindquist, R. Lynfield, Scott Pritchard, Theresa Sokol, Lynn E. Sosa, G. Turabelidze, Sharon M. Watkins, Jon-David Wiesman, Randall W Williams, S. Yendell, J. Schiffer, N. Thornburg   +38 more
semanticscholar   +1 more source