Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Global burden of human brucellosis : a systematic review of disease frequency [PDF]
, 2012 BACKGROUND: This report presents a systematic review of scientific literature published between 1990-2010 relating to the frequency of human brucellosis, commissioned by WHO.
A El Sherbini +40 more
core +13 more sources
Systematic literature review of Rift Valley fever virus seroprevalence in livestock, wildlife and humans in Africa from 1968 to 2016. [PDF]
PLoS Neglected Tropical Diseases, 2018 BACKGROUND:Rift Valley fever virus (RVFV) is a zoonotic arbovirus that causes severe disease in livestock and humans. The virus has caused recurrent outbreaks in Africa and the Arabian Peninsula since its discovery in 1931. This review sought to evaluate
Madeleine H A Clark +4 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Cross-Canada Variability in Blood Donor SARS-CoV-2 Seroprevalence by Social Determinants of Health
Microbiology Spectrum, 2023 We compared the seroprevalence of SARS-CoV-2 anti-nucleocapsid antibodies in blood donors across Canadian regions in 2021. The seroprevalence was the highest in Alberta and the Prairies, and it was so low in Atlantic Canada that few correlates were ...
Sheila F. O’Brien +12 more
doaj +1 more source
Predicting the distribution of canine leishmaniasis in western Europe based on environmental variables. [PDF]
, 2011 The domestic dog is the reservoir host of Leishmania infantum, the causative agent of zoonotic visceral leishmaniasis endemic in Mediterranean Europe. Targeted control requires predictive risk maps of canine leishmaniasis (CanL), which are now explored ...
ADRIAN MYLNE +21 more
core +2 more sources
SARS-CoV-2 population-based seroprevalence studies in Europe: a scoping review
BMJ Open, 2021 Objectives We aimed to review SARS-CoV-2 seroprevalence studies conducted in Europe to understand how they may be used to inform ongoing control strategies for COVID-19.Design Scoping review of peer-reviewed publications and manuscripts on preprint ...
Rebecca Grant +6 more
doaj +1 more source
Estimation of the worldwide seroprevalence of cytomegalovirus : a systematic review and meta-analysis [PDF]
, 2019 Cytomegalovirus (CMV) infection does not usually produce symptoms when it causes primary infection, reinfection, or reactivation because these three types of infection are all controlled by the normal immune system.
Anderholm +31 more
core +2 more sources
Serological Prevalence of Schistosoma japonicum in Mobile Populations in Previously Endemic but Now Non-Endemic Regions of China: A Systematic Review and Meta-Analysis. [PDF]
, 2015 Background: Schistosomiasis japonica has been resurging in certain areas of China where its transmission was previously well controlled or interrupted.
Bian, CR +5 more
core +12 more sources
PLoS Medicine, 2022 BackgroundOur understanding of the global scale of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection remains incomplete: Routine surveillance data underestimate infection and cannot infer on population immunity; there is a ...
Isabel Bergeri +29 more
doaj +1 more source