Results 11 to 20 of about 42,502 (303)

Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro. [PDF]

Molecules, 2023
Zhang B, Yu J, Zhu G, Huang Y, Zhang K, Xiao X, He W, Yuan J, Gao X.   +8 more
europepmc   +2 more sources

A Novel Biotinylated Homotryptamine Derivative for Quantum Dot Imaging of Serotonin Transporter in Live Cells

Frontiers in Cellular Neuroscience, 2021
The serotonin transporter (SERT) is the primary target for selective serotonin reuptake inhibitor (SSRI) antidepressants that are thought to exert their therapeutic effects by increasing the synaptic concentration of serotonin.
Ian D. Tomlinson, Oleg Kovtun, Ruben Torres, Ruben Torres, Laurel G. Bellocchio, Travis Josephs, Sandra J. Rosenthal, Sandra J. Rosenthal, Sandra J. Rosenthal, Sandra J. Rosenthal, Sandra J. Rosenthal, Sandra J. Rosenthal   +11 more
doaj   +1 more source

Selective Serotonin Reuptake Inhibitor Pharmaco-Omics: Mechanisms and Prediction

Frontiers in Pharmacology, 2021
Selective serotonin reuptake inhibitors (SSRIs) are a standard of care for the pharmacotherapy of patients suffering from Major Depressive Disorder (MDD). However, only one-half to two-thirds of MDD patients respond to SSRI therapy. Recently, a “multiple
Thanh Thanh L. Nguyen, Thanh Thanh L. Nguyen, Duan Liu, Ming-Fen Ho, Arjun P. Athreya, Richard Weinshilboum   +5 more
doaj   +1 more source

Milnacipran Inhibits Itch-Related Responses in Mice Through the Enhancement of Noradrenergic Transmission in the Spinal Cord

Journal of Pharmacological Sciences, 2013
We investigated whether milnacipran, a serotonin–noradrenaline reuptake inhibitor, exhibits an antipruritic effect through the spinal action in mice.
Tsugunobu Andoh, Yoshikazu Gotoh, Yasushi Kuraishi   +2 more
doaj   +1 more source

Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor

Frontiers in Pharmacology, 2021
Toludesvenlafaxine hydrochloride dihydrate is a novel chemical entity and a potential triple monoamine reuptake inhibitor. This study characterized the in vitro triple reuptake inhibition activity, antidepressant-like activity in animals, and ...
Haibo Zhu, Wenyan Wang, Chunjie Sha, Wei Guo, Chunmei Li, Fengjuan Zhao, Hongbo Wang, Wanglin Jiang, Jingwei Tian, Jingwei Tian   +9 more
doaj   +1 more source

Psychotropic Drugs for the Management of Chronic Pain and Itch

Pharmaceuticals, 2019
Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants.
Daria A. Belinskaia, Mariia A. Belinskaia, Oleg I. Barygin, Nina P. Vanchakova, Natalia N. Shestakova   +4 more
doaj   +1 more source

Use of selective-serotonin reuptake inhibitors and platelet aggregation inhibitors among individuals with co-occurring atherosclerotic cardiovascular disease and depression or anxiety

SAGE Open Medicine, 2016
Objective: Medications commonly used to treat heart disease, anxiety, and depression can interact resulting in an increased risk of bleeding, warranting a cautious approach in medical decision making.
J Douglas Thornton, Parul Agarwal, Usha Sambamoorthi   +2 more
doaj   +1 more source

Different behavioral effects of maprotiline and fluxilan in rats [PDF]

Archives of Biological Sciences, 2008
Serotonin and noradrenaline are involved in the mechanisms of action of most antidepressant drugs. We examined the effects of chronic treatment with maprotiline, a selective inhibitor of noradrenaline reuptake, and fluxilan, a selective inhibitor of ...
Spasojević Nataša, Gavrilović Ljubica, Dronjak Slađana   +2 more
doaj   +1 more source

Tratamento farmacológico do transtorno obsessivo-compulsivo

Brazilian Journal of Psychiatry, 2001
The pharmacotherapy for obsessive-compulsive disorder (OCD) has started with clomipramine, a potent non-selective serotonin reuptake inhibitor. Newer drugs that selectively inhibit serotonin reuptake (SSRIs) such as fluvoxamine, fluoxetine, paroxetine ...
Carla Marques
doaj   +1 more source

Antidepressant Drugs Effects on Blood Pressure

Frontiers in Cardiovascular Medicine, 2021
Individuals suffering from depressive disorders display a greater incidence of hypertension compared with the general population, despite reports of the association between depression and hypotension.
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi   +9 more
doaj   +1 more source