Results 21 to 30 of about 117,536 (400)

Milnacipran Inhibits Itch-Related Responses in Mice Through the Enhancement of Noradrenergic Transmission in the Spinal Cord

Journal of Pharmacological Sciences, 2013
We investigated whether milnacipran, a serotonin–noradrenaline reuptake inhibitor, exhibits an antipruritic effect through the spinal action in mice.
Tsugunobu Andoh, Yoshikazu Gotoh, Yasushi Kuraishi   +2 more
doaj   +1 more source

Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States [PDF]

, 2014
Objective: To determine whether use of serotonin or non-serotonin reuptake inhibitors near to delivery is associated with postpartum hemorrhage. Design Cohort study. Setting 2000-07 nationwide Medicaid data (Medicaid Analytic eXtract). Population 106 000
Achtyes, Eric D, Hernández-Díaz, Sonia, Huybrechts, Krista F, Michels, Karin B, Mogun, Helen, Palmsten, Kristin, Setoguchi, Soko, Williams, Paige L   +7 more
core   +1 more source

Psychotropic Drugs for the Management of Chronic Pain and Itch

Pharmaceuticals, 2019
Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants.
Daria A. Belinskaia, Mariia A. Belinskaia, Oleg I. Barygin, Nina P. Vanchakova, Natalia N. Shestakova   +4 more
doaj   +1 more source

Preclinical discovery of duloxetine for the treatment of depression [PDF]

, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María, Elorza, Julián, Micó Segura, Juan Antonio, Perez-Caballero, Laura, Torres-Sanchez, Sonia   +4 more
core   +2 more sources

Selective Serotonin Reuptake Inhibitors [PDF]

, 2017
Selective serotonin reuptake inhibitors (SSRIs) are used primarily for treatment of depression and anxiety. Their effectiveness in pain management is limited and inconsistent.
Joshua Matyi, JoAnn T. Tschanz
openaire   +3 more sources

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Use of selective-serotonin reuptake inhibitors and platelet aggregation inhibitors among individuals with co-occurring atherosclerotic cardiovascular disease and depression or anxiety

SAGE Open Medicine, 2016
Objective: Medications commonly used to treat heart disease, anxiety, and depression can interact resulting in an increased risk of bleeding, warranting a cautious approach in medical decision making.
J Douglas Thornton, Parul Agarwal, Usha Sambamoorthi   +2 more
doaj   +1 more source

Different behavioral effects of maprotiline and fluxilan in rats [PDF]

Archives of Biological Sciences, 2008
Serotonin and noradrenaline are involved in the mechanisms of action of most antidepressant drugs. We examined the effects of chronic treatment with maprotiline, a selective inhibitor of noradrenaline reuptake, and fluxilan, a selective inhibitor of ...
Spasojević Nataša, Gavrilović Ljubica, Dronjak Slađana   +2 more
doaj   +1 more source

Serotonin and motherhood: From molecules to mood [PDF]

, 2019
Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain.
Li, Ming, Lonstein, Joseph S., Pawluski, Jodi L.   +2 more
core   +2 more sources

Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine

Molecular Psychiatry, 2018
Depression is a leading cause of disability. Current pharmacological treatment of depression is insufficient, and development of improved treatments especially for treatment-resistant depression is desired.
T. Shuto, M. Kuroiwa, N. Sotogaku, Y. Kawahara, Y. Oh, Jin-Hyeok Jang, Chang-Hoon Shin, Y. Ohnishi, Yuuki Hanada, T. Miyakawa, Yong Kim, P. Greengard, A. Nishi   +12 more
semanticscholar   +1 more source