Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men [PDF]
We compared the effect of vortioxetine, paroxetine and placebo after three days of dosing on sleep architecture. This was a randomised, double-blind, four-way crossover, placebo-controlled, multiple-dose study in 24 healthy young men.
Areberg, J+4 more
core +1 more source
Is there a correlation between venlafaxine therapy during pregnancy and a higher incidence of necrotizing enterocolitis? [PDF]
Background: Novel antidepressant drugs are increasingly used by women of child bearing age. However, potentially harmful effects on fetus and newborn remain unknown. Methods: Case report and literature review.
Treichel, Markus+4 more
core +3 more sources
Kleptomania Induced by Venlafaxine
Introduction. Kleptomania is an impulse-control disorder that results in an irresistible urge to steal. It is often observed as a comorbidity in patients undergoing pharmacological treatment for Parkinson’s disease.
Kumi Sakurada+4 more
doaj +1 more source
Plasma Serotonin and Cardiovascular Outcomes in Chronic Kidney Disease
Background Platelet‐poor plasma serotonin levels are associated with adverse cardiovascular outcomes. Although plasma serotonin levels increase in chronic kidney disease, the cardiovascular implications remain unknown.
Daniel Edmonston+2 more
doaj +1 more source
Influence of mirtazapine on salivary cortisol in depressed patients [PDF]
Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C.+3 more
core +1 more source
Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish [PDF]
Fluoxetine is a selective serotonin reuptake inhibitor that increases serotonin concentration in the central nervous system and modulates various systems, including the control of sympathetic outflow and the hypothalamus–pituitary–adrenal. However, it is
Murilo S. Abreu+4 more
doaj +2 more sources
It has been estimated that 20% of pregnant women suffer from depression and it is well-documented that maternal depression can have long-lasting effects on the child.
J. Olivier+6 more
semanticscholar +1 more source
De‐Saturation of Single‐Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions
De‐saturation of copper‐based single‐atom catalysts (De‐sat SACs) are realized by a KOH‐mediated Joule thermal shock strategy. Benefiting from the under‐saturation coordination environment of single‐atom Cu center, De‐sat Cu SACs exhibit remarkable catalytic activity in propargylic substitution reactions, tolerating a broad range of nucleophiles (N–, C–
Qilong Cai+12 more
wiley +1 more source
Fluoxetine Prevents the Development of Depressive-like Behavior in a Mouse Model of Cancer Related Fatigue [PDF]
Cancer patients frequently suffer from fatigue, a complex syndrome associated with tiredness and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, escalates during treatment, and can persist for years after treatment ...
Bicer, Sabahattin+7 more
core +2 more sources
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang+20 more
wiley +1 more source