Results 71 to 80 of about 117,536 (400)

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science, EarlyView.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
wiley   +1 more source

Effect of glibenclamide on antinociceptive effects of antidepressants of different classes

Clinics, 2011
OBJECTIVES: The purpose of this work was to determine whether the intraperitoneal administration of glibenclamide as a K ATP channel blocker could have an effect on the antinociceptive effects of antidepressants with different mechanisms of action ...
Valiollah Hajhashemi, Bahareh Amin
doaj   +1 more source

Serotonin syndrome induced by overdose of atomoxetine alone in a patient with attention‐deficit hyperactivity disorder: A case report

PCN Reports, 2022
Background Serotonin syndrome is characterized by mental status changes, autonomic hyperactivity, and neuromuscular abnormalities. This syndrome results from various medications that engender serotonergic overactivity.
Fumika Sato, Akihito Suzuki, Keisuke Noto, Toshinori Shirata, Muneaki Kanno, Ryota Kobayashi, Koichi Otani   +6 more
doaj   +1 more source

The reported use and effectiveness of Hypericum (St John’s wort) on affective symptoms in a depression self-help group [PDF]

, 2002
A recent meta-analysis suggested that Hypericum perforatum (St John’s wort) is an effective treatment for mild to moderate depression and may have a superior side-effect profile to some antidepressant drugs.
Baldwin, D.S., Dyson, R., Jenkins, G., Mayers, A.G., Tiernan, A.   +4 more
core   +1 more source

Selective serotonin reuptake inhibitors pathway [PDF]

Pharmacogenetics and Genomics, 2009
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that influences multiple processes, including autonomic function, motor activity, hormone secretion, cognition, and complex processes associated with affection, emotion, and reward [1]. In the terminal axon of the serotonergic neuron, free tryptophan (TRP) is converted to 5-HT [2].
Teri E. Klein, Russ B. Altman, Katrin Sangkuhl   +2 more
openaire   +3 more sources

Defining Sex‐ and Age‐Specific Initial Stay Times for Continuous Moderate‐Intensity Work in Hot Environments Before Heat‐Mitigation Controls Are Implemented – Part A

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Rationale Industry guidelines recommend work‐rest allocations to limit increases in core temperature (Tcore; > 38.0°C or > Δ1.0°C above resting) during work in the heat. However, the initial duration of permissible work before implementing these allocations is not specified (initial stay time [IST]) and individual factors such as sex and age ...
Fergus K. O'Connor, Kristina‐Marie T. Janetos, Brodie J. Richards, Roberto C. Harris‐Mostert, Katie E. Wagar, Leonidas G. Ioannou, James J. McCormick, Robert D. Meade, Emily J. Tetzlaff, Ronald J. Sigal, W. Shane Journeay, Glen P. Kenny   +11 more
wiley   +1 more source

Fluvoxamine-induced reversible euprolactinemic galactorrhea in a case of obsessive-compulsive disorder

Annals of Indian Psychiatry, 2017
Fluvoxamine is one of the commonly used selective serotonin reuptake inhibitors (SSRIs) as a first-line treatment for obsessive-compulsive disorder (OCD).
Chetan Dilip Vispute, Shubhangi R Parkar, Deepika A Singh   +2 more
doaj   +1 more source

Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. [PDF]

, 2018
Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these ...
Barsoum, Amir, Benkelfat, Chawki, Berney, Alexandre, Cottraux, Jean, Diksic, Mirko, Gravel, Paul, Leyton, Marco, Lissemore, Jennifer I, Nordahl, Thomas E, Pinard, Gilbert, Sibon, Igor, Sookman, Debbie   +11 more
core   +2 more sources

Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants, Prolactin and Breast Cancer

Frontiers in Oncology, 2012
Selective serotonin reuptake inhibitors (SSRIs) are a widely prescribed class of antidepressants. Laboratory and epidemiologic evidence suggests that a prolactin-mediated mechanism secondary to increased serotonin levels at neuronal synapses could lead ...
J. E. Ashbury, L. Lévesque, Patricia A. Beck, K. Aronson   +3 more
semanticscholar   +1 more source

Defining Sex‐ and Age‐Specific Initial Stay Times for Continuous Heavy‐Intensity Work in Hot Environments Before Heat‐Mitigation Controls Are Implemented—Part B

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Rationale Industry guidelines recommend work‐rest schedules to prevent unsafe core temperature elevations (> 38.0°C or > Δ1.0°C above baseline resting) in an “average” worker exposed to occupational heat stress. While permissible initial work durations (initial stay times [IST]) before implementing rest schedules have been suggested, existing ...
Fergus K. O'Connor, Kristina‐Marie T. Janetos, Brodie J. Richards, Roberto C. Harris‐Mostert, Katie E. Wagar, Leonidas G. Ioannou, James J. McCormick, Robert D. Meade, Emily J. Tetzlaff, Ronald J. Sigal, W. Shane Journeay, Glen P. Kenny   +11 more
wiley   +1 more source