Results 151 to 160 of about 141,303 (265)

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Integrating Serological and Molecular Data to Characterize Fowl Adenovirus Associated With Inclusion Body Hepatitis in Broiler Chickens From Malaysia. [PDF]

Vet Med Sci
Bhuiyan MSA, Nath BK, Sam LM, Balakrishnan KN, Gupta SD, Sarker S.   +5 more
europepmc   +1 more source

Targeted liquid chromatography–tandem mass spectrometry profiling of arginine and histidine derivatives in chronic migraine: Discriminatory performance and changes after onabotulinumtoxinA therapy

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary People with chronic migraine may have changes in amino‐acid metabolism, but it remains unclear which metabolic pathways are associated with the disease and early response to onabotulinumtoxinA treatment. We measured plasma amino‐acid levels in patients with chronic migraine and healthy controls and assessed changes after 1 month ...
Seyma Dumur, Kadidiatou Diarra, Joudy Sewidan, Julie Jalila Kalmoni, Demet Aygun, Dildar Konukoglu, Hafize Uzun   +6 more
wiley   +1 more source

Molecular detection and <i>VP1</i>-based phylogenetic characterization of Foot-and-mouth disease virus serotype O circulating in cattle in Aceh, Indonesia. [PDF]

Vet World
Ak MD, Abrar M, Ferasyi TR, Darniati D, Erina E, Siregar TN, Setiyaningsih S.   +6 more
europepmc   +1 more source

Legionella pneumophila pneumonia in South Eastern Sydney: diagnosis, prognosis and public health outcomes

Internal Medicine Journal, EarlyView.
Abstract Background Legionellosis causes more severe disease than other aetiologies of community‐acquired pneumonia (CAP). Early recognition and treatment of Legionella pneumonia reduce mortality. Urinary antigen testing (UAT) has facilitated rapid and reliable diagnosis of Legionella pneumonia. Aims The aims of this study were as follows: (i) identify
Sue Qian, Nickson Ning, Kelli Snyders, Misha Klingstrom, Pam Konecny, Vicky Sheppeard, Rachael Roberts, Georgia Shimmin, Robert Stevens, Richard Sullivan   +9 more
wiley   +1 more source

Isolation and molecular characterization of foot-and-mouth disease viruses from small ruminants in Nigeria. [PDF]

Vet Res
Ehizibolo DO, Oyekan O, Oguche MO, Ardo A, Ludi AB, Wood BA, Gubbins S, Hicks HM, Wadsworth J, Chevanne E, Rosso F, Knowles NJ, Mioulet V, King DP, Limon G.   +14 more
europepmc   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Serotype distribution and coverage by pneumococcal vaccines in hospitalised adults with pneumococcal pneumonia in Germany. [PDF]

ERJ Open Res
Karssen D, Hessels LM, Barten-Neiner G, Bauer W, Franch-Arroyo S, Fühner T, Hassiepen CO, Heigener DF, Hullegie S, Jahja R, Johnson KD, Kremling J, Pletz MW, Roberts CS, Rohde GGU, Ruggieri M, Schneider J, Stolz D, Swarthout TD, Weiss T, Van Werkhoven CH, Witzenrath M, Bonten MJM, Prat Aymerich C.   +23 more
europepmc   +1 more source

Characterisation of HIV‐1 Gag Cytotoxic T‐Lymphocyte Epitopes in the Southern African Region—A Systematic Review

Immunology, EarlyView.
Distribution of studies on HIV‐1 Gag cytotoxic T‐lymphocyte epitopes in the southern African region showing that the majority of studies (58.44%) were conducted in South Africa, followed by Botswana (15.58%), Zambia (10.39%), Malawi (7.79%), Zimbabwe (6.49%), and Angola (1.30%).
Tumelo L. Fortuin, Paballo Nkone, Shayne Loubser, Caroline T. Tiemessen, Simnikiwe H. Mayaphi   +4 more
wiley   +1 more source

Genomic surveillance of post-immunization pneumococcal carriage in Ghana. [PDF]

Microb Genom
Akwetey SA, Kwenda S, Addy HPK, Nyarko EF, Fiam E, Quansah E, Donkor IE, Acheampong DO, Kwakye-Nuako G, Abdullah MR, Hammerschmidt S, Ismail A, Mills RO.   +12 more
europepmc   +1 more source