ABSTRACT Sutimlimab is a monoclonal antibody against complement fraction C1s approved for the treatment of hemolytic anemia due to cold agglutinin disease (CAD). Here, we analyzed and report the largest international CAD cohort of sutimlimab‐treated patients ever reported to highlight its safety and effectiveness in the real‐world setting. We accrued a
Bruno Fattizzo +38 more
wiley +1 more source
Epidemiology, Clinical Spectrum, and Serotype Distribution of NS1-Confirmed Dengue Cases in Andhra Pradesh, India: A Decade-Long Retrospective Study. [PDF]
Sireesha K +7 more
europepmc +1 more source
Abstract BACKGROUND Adeno‐Associated Virus vectors are widely used in gene therapy due to their safety and efficacy. Despite the interest in their therapeutical application, AAV purification remains a significant challenge. Density gradient ultracentrifugation using cesium chloride, sucrose, or iodixanol gradients are common methods for AAV ...
Sabrina Leigheb +6 more
wiley +1 more source
Serum as an alternative matrix for reliable molecular diagnosis of fowl adenovirus infections. [PDF]
Kardoudi A +4 more
europepmc +1 more source
Systemic Immunosuppression to Reduce Surgical Intervention in ANCA‐Negative Subglottic Stenosis
Idiopathic subglottic stenosis (iSGS) typically follows an indolent course managed with surgical dilatation, though a subset demonstrates aggressive, recurrent disease. In this retrospective cohort study, systemic immunosuppression significantly prolonged inter‐dilation intervals in both granulomatosis with polyangiitis‐associated SGS and an “atypical”
Guy Benshetrit +5 more
wiley +1 more source
Pneumococci detected in sterile body fluids of pediatric patients postpandemic trends from a single center. [PDF]
Üstündağ G +11 more
europepmc +1 more source
Vaccination and transfusion safety at the time of expanding use of live attenuated vaccines
Vox Sanguinis, EarlyView.
Pierre Tiberghien +4 more
wiley +1 more source
From Meat to Plant‐Based Products? The Enduring Impact of BSE on Beef Consumption
ABSTRACT This study reassesses the impact of the historical BSE outbreak on EU diets, showing that consumption patterns shifted persistently even after policy actions eliminated the food safety risk. Utilizing advanced difference‐in‐differences techniques on 1980–2020 data, we demonstrate that while beef consumption exhibited a transient U‐shaped ...
Jader Velásquez, Shon Ferguson
wiley +1 more source
Serotypes, MIC-Based Antimicrobial Susceptibility, and Genotypic Diversity of <i>Actinobacillus pleuropneumoniae</i> Isolates from Diseased Pigs in Brazil. [PDF]
Costa BLP +6 more
europepmc +1 more source
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source

