Results 271 to 280 of about 135,799 (323)

A Genome‐Wide Screening of Novel Immunogenic TrLSDV103 Protein of Lumpy Skin Disease Virus and Its Application for DIVA

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Using the VirScan platform covering 4522 LSDV protein sequences, sera from 20 LSDV‐infected and 20 GTPV‐vaccinated cattle were used to screen phage libraries. Sequencing and bioinformatics analyses revealed peptides covering the TrLSDV103 protein. The candidate antigen was subsequently expressed, confirmed for its DIVA capability, and used to develop ...
Xinwei Yuan, Junhua Dong, Zhijie Xiang, Qian Zhang, Pan Tao, Aizhen Guo   +5 more
wiley   +1 more source

On the verge: outbreak risk after two years of record-breaking dengue epidemics in Brazil. [PDF]

Lancet Reg Health Am
Lopes R, Bastos LS.
europepmc   +1 more source

Intensification of rAAV Production Based on HEK293 Cell Transient Transfection

Biotechnology Journal, Volume 20, Issue 6, June 2025.
Graphical Abstract and Lay Summary ABSTRACT Recombinant adeno‐associated virus (rAAV) vectors are widely used in gene therapies, but the rapidly increasing global demand has created a significant challenge for rAAV manufacturing, where production capacity remains a critical bottleneck.
Ye Zhang, Emil Sundäng Peters, Olalekan Daramola, Trudy Ann Tucker, Johan Rockberg, Diane Hatton, Véronique Chotteau   +6 more
wiley   +1 more source

Systematic review on serotypes distribution of pneumococcal pneumonia in adults and the elderly. [PDF]

BMC Public Health
Mrabt F, Guedes S.
europepmc   +1 more source

Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

Biotechnology and Bioengineering, Volume 122, Issue 6, Page 1424-1440, June 2025.
ABSTRACT Increasing demand for recombinant adeno‐associated virus (rAAV)‐based gene therapies necessitates increased manufacturing production. Transient transfection of mammalian cells remains the most commonly used method to produce clinical‐grade rAAVs due to its ease of implementation.
Tam N. T. Nguyen, Damdae Park, Christopher T. Canova, Jose Sangerman, Prasanna Srinivasan, Rui Wen Ou, Paul W. Barone, Caleb Neufeld, Jacqueline M. Wolfrum, Stacy L. Springs, Anthony J. Sinskey, Richard D. Braatz   +11 more
wiley   +1 more source

Chemical synthesis elucidates the absolute configuration and key antigenic epitope of <i>Vibrio cholerae</i> serotype O100 O-antigen. [PDF]

Sci Adv
Chen G, Tian G, Hu J, Qin C, Zou X, Cai J, Lv G, Gao W, Seeberger PH, Yin J.   +9 more
europepmc   +1 more source

Hepatitis B Virus X Protein Upregulates SREBP2 to Modulate Autophagy in Hepatocellular Carcinoma

Cancer Medicine, Volume 14, Issue 11, June 2025.
This study reveals that Hepatitis B virus X protein can up‐regulate SREBP2 expression, augment cholesterol synthesis, and enhance autophagy flux, providing a new theoretical basis for the contribution of abnormal lipid metabolism caused by chronic HBV infection to the inflammatory–carcinoma transformation.
Qiuyan Lin, Yongxu Lin, Yongzhu Huang, Mingrong Wang, Xiaoxia Xie, Weiqi Cai, Qilan Guo, Pingying Jiang, Yuanlin Qi, Dan Li   +9 more
wiley   +1 more source

SeroBA(v2.0) and SeroBAnk: a robust genome-based serotyping scheme and comprehensive atlas of capsular diversity in Streptococcus pneumoniae

Lorenz O, King AC, Hung HCH, Ganaie FA, Wyllie AL, Manna S, Satzke C, van der Linden M, Ravenscroft N, Slotved H, McGee L, Nahm MH, Bentley SD, Lo SW.   +13 more
europepmc   +1 more source

Population structure, antibiotic resistance and molecular characteristics of <i>Streptococcus pneumoniae</i> causing invasive disease in Hubei, China. [PDF]

J Med Microbiol
Song J, Zhang H, He S, Yuan H, Chen Y.
europepmc   +1 more source

Bacterial Outer Membrane Vesicles: From Physics to Clinical

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou, Shuang Zou, Derong Dai, Liqing He, Xingyu Mou, Ninglin Zhao, Hong Li, Rui Bao   +7 more
wiley   +1 more source