ABSTRACT Dengue is a leading cause of viral hemorrhagic fever globally, with hepatic involvement being common but usually mild. Rarely, dengue can progress to fulminant hepatic failure, a life‐threatening complication requiring prompt recognition especially in resource‐limited settings.
Mohamed Bushra Alajab +7 more
wiley +1 more source
Prevalence of Candidate Vaccine Targets and Genomic Features of Pediatric Invasive Streptococcus Agalactiae in Japan. [PDF]
Kasai M +9 more
europepmc +1 more source
Herpes Simplex Virus Infection With Multiple Cerebral Hemorrhages: A Case Report
ABSTRACT Herpes simplex virus (HSV) infection may trigger rare vascular complications that lead to multiple cerebral hemorrhages. This case emphasizes considering HSV in unexplained cerebral hemorrhage among immunocompromised individuals with systemic symptoms, as timely antiviral treatment effectively improves clinical outcomes.
Zhongzhan Wu +4 more
wiley +1 more source
Serotype distribution and antimicrobial resistance of <i>Streptococcus pneumoniae</i> in paediatric patients in Japan (2020-2023). [PDF]
Nakano S +9 more
europepmc +1 more source
Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model
DFNB16 is among the most prevalent forms of congenital deafness, caused by mutations in the Stereocilin gene. Although no treatment currently exists, gene therapy represents a promising curative approach. Here, we demonstrate that AAV‐mediated gene delivery in a DFNB16 mouse model restored both peripheral hearing and central auditory processing ...
Sepideh Iranfar +12 more
wiley +1 more source
Comparative genomic analysis of hypervirulent group B streptococcus of ST12/serotype Ib suggests potential virulence factors. [PDF]
Zhou K, Sun Z, Sun J, Xu X, Guan M.
europepmc +1 more source
Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie +16 more
wiley +1 more source
Immunogenicity of a 20-Valent Pneumococcal Conjugate Vaccine Versus a 13-Valent Vaccine in Infants: A Systematic Review and Meta-Analysis. [PDF]
Pacheco-Haro MD +8 more
europepmc +1 more source

