Results 331 to 340 of about 219,974 (370)

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Crizotinib induces excessive accumulation of squalene epoxidase (SQLE) by blocking its autophagic degradation. This accumulation disrupts cholesterol and sphingolipid metabolism, leading to hepatic steatosis or hepatocyte apoptosis, respectively. Autophagy activators, such as metformin, or SQLE enzymatic inhibitors, like terbinafine, possesses the ...
Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo   +14 more
wiley   +1 more source

Isolation, Identification, and Molecular Genetic Characteristics of a Pathogenic Strain of Streptococcus suis Serotype 3. [PDF]

Pathogens
Wang L, Qiu J, He B, Wu X, Chen Q, Wang Q, Wu R, Zheng B, Zhou L, Huang X.   +9 more
europepmc   +1 more source

Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome

Advanced Science, Volume 12, Issue 14, April 10, 2025.
A new CdCS rat model is developed using CRISPR‐Cas9 technology. It shows impairments in cognitive and social behaviors, neuronal dendrite abnormalities in the hippocampus and mPFC, and inflammatory and immune processes in mPFC brain cells. Early AAV‐Ctnnd2 gene therapy enhances cognitive function in CdCS rats.
Jingjing Shen, Yan Wang, Yang Liu, Junying Lan, Shuang Long, Yingbo Li, Di Chen, Peng Yu, Jing Zhao, Yongjun Wang, Shali Wang, Feng Yang   +11 more
wiley   +1 more source

Investigation of severe dengue outbreak in Maumere, East Nusa Tenggara, Indonesia: Clinical, serological, and virological features. [PDF]

PLoS One
Santoso MS, Nara MBR, Nugroho DK, Yohan B, Purnama A, Boro AMB, Hayati RF, Gae EP, Denis D, Rana B, Hibberd ML, Sasmono RT.   +11 more
europepmc   +1 more source

Escherichia coli in the production of biopharmaceuticals

Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.
Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley   +1 more source

Modelling the Epidemiological Impact of Different Adult Pneumococcal Vaccination Strategies in the United Kingdom. [PDF]

Infect Dis Ther
Oidtman RJ, Meleleo G, Sharomi O, Matthews IR, Ntais D, Nachbar RB, Malik TM, Bakker KM.   +7 more
europepmc   +1 more source

Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep

Brain and Behavior, Volume 15, Issue 4, April 2025.
Sheep with CLN5 Batten disease that received combination intracerebroventricular and intravitreal gene therapy underwent MRI scanning to assess global and regional brain volumes and determine the value of MRI to detect therapeutic efficacy. Sheep that were treated pre‐symptomatically underwent longitudinal scanning between 5 and 18 months of age, while
Samantha J. Murray, Mustafa M. Almuqbel, Simon A. Felton, Nickolas J. Palmer, Ashley R. Deane, Daniel J. Myall, Reza Shoorangiz, Arsène Ella, Matthieu Keller, David N. Palmer, Tracy R. Melzer, Nadia L. Mitchell   +11 more
wiley   +1 more source

Lichen and Its Microbiome as an Untapped Source of Anti‐Biofilm Compounds

Chemistry &Biodiversity, Volume 22, Issue 4, April 17, 2025.
Lichens and their associated fungi give rise to the evaluation of several extracts and compounds against biofilms. ABSTRACT Lichen substances have been first described in the 1870s, and around 10 000 compounds have been isolated and characterized. Most of them have been evaluated for their activity on planktonic microorganisms (bacteria and fungi ...
Marion Millot, Christine Imbert, Christelle Pouget, Marion Girardot, Lengo Mambu   +4 more
wiley   +1 more source

The Complex Landscape of Updated Pneumococcal Conjugate Vaccines. [PDF]

Open Forum Infect Dis
Thindwa D, Shapiro ED, Weinberger DM.
europepmc   +1 more source

The inactivated and ISA 61 VG adjuvanted vaccine enhances protection against cross-serotype Listeria monocytogenes. [PDF]

Vet Res
Meng F, Wang Y, Chen C, Pan T, Li J, Xu Y, Wang Z, Yao H, Jiao X, Yin Y.   +9 more
europepmc   +1 more source