Results 241 to 250 of about 42,797 (295)

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

Streptococcus suis infection as an emerging zoonotic threat in Brazil: a One Health-based review. [PDF]

Rev Inst Med Trop Sao Paulo
Farias LABG, Viana Neto OM, Lima Sobrinho EP, de Melo AGND, Pontes IM, Gonçalves BBS, Benevides HP, Maia SPO, Rodrigues JLN, Perdigão Neto LV.   +9 more
europepmc   +1 more source

An Ad5‐Based COVID‐19 Vaccine Encoding SARS‐CoV‐2 Spike Glycoprotein Induces Measurable Antibody and Cytokine Responses in Mice

Biotechnology Journal, Volume 21, Issue 3, March 2026.
Graphical Abstract and Lay Summary A recombinant adenovirus type 5–based vaccine encoding the full‐length SARS‐CoV‐2 Spike glycoprotein (Ad5Spike) was evaluated for its ability to induce cellular and humoral immune responses in BALB/c mice. Immunization with Ad5Spike resulted in the generation of antigen‐specific cellular immunity, characterized by ...
Fulya Erendor, Fatih Uzer, Salih Sanlioglu   +2 more
wiley   +1 more source

Unlocking the Pathological Insights of the Bacterial Infections of Free-Living Pigeons. [PDF]

Vet Med Sci
Fotouh A, Elbarbary NK, Elshafae S, El-Hawary SF, Al-Shahari EA, Alharbi HM, Aljumaa MA, Almasoudi SH, Ahmed AE, Diab MS, Mahmoud MA, Zaki RS.   +11 more
europepmc   +1 more source

From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery

Biopolymers, Volume 117, Issue 2, March 2026.
ABSTRACT Polymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient encapsulation of both hydrophilic and lipophilic drugs, making them promising for drug delivery.
Milena Ferreira de Lima, Andy Joel Taipe Huisa, Azael da Silva Neto, Clarice Beatriz Gonçalves Silva, Iago Dillion Lima Cavalcanti, Karolliny Barbosa de Araújo, Mariane Cajubá de Britto Lira‐Nogueira, Nereide Stela Santos Magalhães, Priscila Gubert   +8 more
wiley   +1 more source

Two different genotypes of <i>Vibrio parahaemolyticus</i> serotype O10:K4 have been co-circulating in Shanghai since 2020. [PDF]

Microb Genom
Wang C, Zhang W, Lin Q, Chen Y, Jiang H, Zhou J, Li B, Li P, Zhuang Y, Chen M, Chen H.   +10 more
europepmc   +1 more source

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Goyazensolide and Centratherin Isolated From Eremanthus crotonoides by High‐Speed Countercurrent Chromatography

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT In this study, bioassay‐guided fractionation of the ethanolic extract from Eremanthus crotonoides leaves enabled the isolation of two bioactive sesquiterpene lactones, centratherin and goyazensolide, which were evaluated for their antimycobacterial and anti‐inflammatory properties.
Natalie Giovanna da Rocha Ximenes, Sanderson Dias Calixto, Thatiana Lopes Biá Ventura Simão, Elena B. Lassunskaia, Patrícia de Homobono de Brito Moura, Ivana Ramos Correa Leal, Michelle Frazão Muzitano, Shaft Corrêa Pinto   +7 more
wiley   +1 more source

AI-Enhanced FT-IR Spectroscopy: Evaluation of a Novel Tool for High-Throughput Serovar Typing of <i>Salmonella enterica</i> subsp. <i>enterica</i> in Croatia. [PDF]

Pathogens
Dopuđ M, Šuto S, Tomašković D, Hlebić L, Peinović L, Špičić S, Zdelar Tuk M, Reil I, Humski A, Kompes G, Strugar SŠ, Papić B, Avberšek J, Mikolajczak A, Duvnjak S.   +14 more
europepmc   +1 more source

A Case Series of Hypermucoid Klebsiella pneumoniae Liver Abscess in Caucasian Americans Without Travel History: An Epidemiologic Shift?

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging cause of community‐acquired pyogenic liver abscess (PLA), classically described in East and Southeast Asia. We report two cases of hvKp‐associated PLA in Caucasian women of American origin with no history of international travel, animal exposure, or Asian food consumption. Both patients
Krishna Sai Kiran Sakalabaktula, Sameer Kumar Majety, Sri Ratna Divya Nanduri, Divya Durga, David Kreps, Devi Prasad Botu, Gopichand Muppana   +6 more
wiley   +1 more source