Results 281 to 290 of about 69,583 (343)

Engineering of High‐Yield Recombinant Adeno‐Associated Virus Producer Plasmids

Biotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary Recombinant adeno‐associated viruses (AAV) are important in gene therapy but their production may be impaired by non‐optimized gene design. In this study, the authors demonstrate that production was best when the AAV replicase gene was in a wild‐type configuration while the complexity of other genetic elements could ...
Marco T. Radukic, Dinh To Le, Robert Freudenberg, Anne Hammann, Omar Hamdan, Claire Rothschild‐Gronau, Raimund Hoffrogge, Susanne K. Golm, Rebecca C. Feiner, Kathrin E. Teschner, Kristian M. Müller   +10 more
wiley   +1 more source

Antimicrobial resistance and virulence profiling of waterfowl-derived Salmonella in Sichuan from 2021 to 2023. [PDF]

Poult Sci
Ji X, Li X, Zhang L, Zhu D, Liu M, Wang M, Jia R, Chen S, Wu Y, Zhang S, Sun D, Cheng A, Zhao X.   +12 more
europepmc   +1 more source

Downstream Process Intensification for AAV Purification by Affinity Chromatography Using Single Pass Tangential Flow Filtration

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 174-185, January 2026.
ABSTRACT To enable adeno‐associated viral vectors (AAV) to achieve their maximum potential, next‐generation manufacturing processes must be developed to make gene therapies more affordable and accessible. This study focused on the design of two different intensified AAV downstream manufacturing processes at bench and pilot scale.
Akshay S. Chaubal, Ronny Horax, Christopher J. Yehl, S. Ranil Wickramasinghe, Xianghong Qian, Lu Wang, Andrew L. Zydney   +6 more
wiley   +1 more source

Lanka virus, a Mus booduga-borne orthohantavirus infection-associated febrile illness in Sri Lanka. [PDF]

PLoS Negl Trop Dis
Muthusinghe DS, Senarathne P, Shimizu K, Sarathkumara YD, Nanayakkara S, Lokupathirage SMW, Wei Z, Rathnayake NS, Vijeyakumaran R, Koizumi N, Kawakami T, Koizumi A, Harada KH, Dissanayake N, Kularathne SAM, Tsuda Y, Urata S, Arikawa J, Gamage CD, Yoshimatsu K.   +19 more
europepmc   +1 more source

Could the Biological Potency of Porcelia macrocarpa R.E. Fries (Annonaceae) be Linked to Its Diverse Metabolite Profile?

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Porcelia macrocarpa is a Brazilian plant species belonging to the Annonaceae family. To date, more than 190 compounds have been identified and/or isolated from this species, with terpenoids comprising the majority (62%). Alkaloids represent the second most abundant class (11%), followed by steroids (4%), acetogenins (4%), fatty acids (4 ...
Fernanda Thevenard, Ivanildo A. Brito, Emerson A. Oliveira, Mariana H. Chaves, João Henrique G. Lago   +4 more
wiley   +1 more source

Simultaneous circulation of all four dengue virus serotypes during a single outbreak in Kassala, Eastern Sudan 2023. [PDF]

BMC Infect Dis
Musa AO, Awadap MIM, Faki MTM, Ibrahim HA, Adam A, Siddig EE, Ahmed A, Hamdan HZ, Ahmed EA, Abdallah TM.   +9 more
europepmc   +1 more source

Fulminant Hepatic Failure in Dengue Infection: Two Survivors From a Resource‐Limited Outbreak in Sudan

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Dengue is a leading cause of viral hemorrhagic fever globally, with hepatic involvement being common but usually mild. Rarely, dengue can progress to fulminant hepatic failure, a life‐threatening complication requiring prompt recognition especially in resource‐limited settings.
Mohamed Bushra Alajab, Sawsan Ahmed Omer Elameen, Fatima Abdelmonem Yousif Mohamed, Mohamed Glal Mahmoud Eisa, Eman Osama Mohammed Omer, Mohab Abdallhameed Hassan Elmubarak, Mohannad Abdallhameed Hassan Elmubarak, Mumen Abdalazim Dafallah   +7 more
wiley   +1 more source

Genomic evidence links human dengue cases with undetermined serotypes to sylvatic lineages. [PDF]

Trop Med Health
Suppiah J, Zulkifli MMS, Adiee AH, Zainudin NAZ, Dukut Soeharto ME, Ramli N, Wan MK, Sulong MR, Suli Z, Mohd Zain R.   +9 more
europepmc   +1 more source

Herpes Simplex Virus Infection With Multiple Cerebral Hemorrhages: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Herpes simplex virus (HSV) infection may trigger rare vascular complications that lead to multiple cerebral hemorrhages. This case emphasizes considering HSV in unexplained cerebral hemorrhage among immunocompromised individuals with systemic symptoms, as timely antiviral treatment effectively improves clinical outcomes.
Zhongzhan Wu, Fangfang Liu, Fugui Wang, Jie Li, Houqing Lu   +4 more
wiley   +1 more source

Fourier-transform infrared spectroscopy for rapid <i>Streptococcus pneumoniae</i> serotyping in a tertiary care general hospital. [PDF]

Front Microbiol
Campos-Ruiz M, Wang-Wang JH, Bordoy AE, Rodríguez-Ponga B, Pagan N, Hidalgo J, Quesada MD, Giménez M, Cardona PJ.   +8 more
europepmc   +1 more source