Results 41 to 50 of about 29,788 (120)

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

The intratumoral microbiota biomarkers for predicting survival and efficacy of immunotherapy in patients with ovarian serous cystadenocarcinoma

Journal of Ovarian Research
Background Ovarian serous cystadenocarcinoma, accounting for about 90% of ovarian cancers, is frequently diagnosed at advanced stages, leading to suboptimal treatment outcomes.
Hao Qin, Jie Liu, Yi Qu, Yang-Yang Li, Ya-Lan Xu, Yi-Fang Yan   +5 more
doaj   +1 more source

Clinicopathologic study of malignant ovarian tumors: A study of fifty cases

Medical Journal of Dr. D.Y. Patil University, 2017
Background: Malignant ovarian tumors have worst prognosis among all gynecological malignancies and highest case fatality rate. There is a steady increase in the age-standardized incidence rate in India.
Shirish S Chandanwale, Rahul Jadhav, Ruby Rao, Piyusha Naragude, Sunita Bhamnikar, Jehan Nizam Ansari   +5 more
doaj   +1 more source

NTAQ1 Promotes Hepatocellular Carcinoma Growth by Facilitating the Protein Degradation of the Tumor Suppressor PRDM2

Cancer Science, Volume 117, Issue 10, Page 2803-2818, October 2026.
Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara, Hajime Otsu, Taro Tobo, Kiyotaka Hosoda, Tadashi Abe, Masahiro Hashimoto, Yusuke Nakano, Katsushi Dairaku, Yuya Ono, Yuki Miyata, Chihiro Matsumoto, Takanari Tatsumi, Satoshi Higuchi, Takashi Ofuchi, Akinori Tsujimoto, Yuki Ando, Qingjiang Hu, Yusuke Yonemura, Akira Shimizu, Takaaki Masuda, Yuji Soejima, Koshi Mimori   +21 more
wiley   +1 more source

Pancreatic cystadenoma and cystadenocarcinoma

, 1984
Cystadenomas and cystadenocarcinomas are rare but not exceptional tumours of the pancreas. In this report six cases are added to the more than 300 cystadenomas and over 100 cystadenocarcinomas reported in the literature.
von Segesser, L., Rohner, A.
core   +1 more source

Triazole‐Linked Pyrimidine Nucleoside Dimers: Design, Synthesis, and Applications in Medicinal and Nucleic Acid Chemistry. Part IV

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
A series of 18 pyrimidine nucleoside dimers analogues with a short 1,4‐disubstituted 1,2,3‐triazole linkage were synthesized using a click chemistry approach (CuAAC). Analysis of the obtained products was conducted utilizing 1D/2D NMR spectroscopy (1H, 13C, 19F, 15N, and 29Si), mass spectrometry (ESI‐MS), and high‐performance liquid chromatography ...
Dagmara Baraniak, Dariusz Wawrzyniak, Daniel Baranowski   +2 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, Volume 20, Issue 9, Page 2220-2242, September 2026.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Malignant mixed epithelial tumour of ovary-serous papillary cystadenocarcinoma and transitional cell carcinoma with tubo-ovarian torsion: A rare tumour with rare presentation [PDF]

, 2013
Ovarian torsion can be associated with various pathophysiological factors. Most commonly, benign epithelial ovarian tumours present with torsion. We present an unusual case of mixed malignant epithelial ovarian tumour with a predominant component of high-
Nor Fathihah binti Mamat
core   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 9, Page 2323-2339, September 2026.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Spontaneous rupture of malignant ovarian cyst in 8-gestation-week pregnancy: A case report and literature review [PDF]

Archive of Oncology, 2011
Ovarian cancer takes the second place in the incidence of all genital carcinomas occurring in pregnancy. In spite of a low overall incidence of ovarian cancer in pregnancy and, in most cases, asymptomatic clinical picture, the routine use of ...
Mladenović-Segedi Ljiljana, Mandić Aljoša, Segedi Dimitrije, Kozarčić Tatjana   +3 more
doaj   +1 more source