Results 91 to 100 of about 2,210,951 (366)

Micropulse laser for persistent optic disc pit maculopathy. A case report

American Journal of Ophthalmology Case Reports, 2018
Purpose: Optic disc pits (ODP) are rare and congenital anomalies of the optic disc, sometimes remaining asymptomatic. However, serous macular detachment or optic disc maculopathy is the most common complication, causing significant visual deterioration ...
Carlos Andrés Valdés-Lara, Nicolás Crim, Gerardo García-Aguirre, Ismael Ávila Lule, Virgilio Morales-Cantón   +4 more
doaj   +1 more source

Medical treatment of early stage and rare histological variants of epithelial ovarian cancer [PDF]

, 2015
Epithelial ovarian cancer is often considered a single pathological entity, but increasing evidence suggests that it is rather a group of different neoplasms, each with unique pathological characteristics, molecular features, and clinical behaviours ...
Biglia, Nicoletta, CODACCI PISANELLI, Giovanni, Colombo, Nicoletta, Cont, Nicoletta Tomasi, D'Alonzo, Marta, Ferrero, Annamaria, Peccatori, Fedro Alessandro   +6 more
core   +3 more sources

Morphologic and Immunocytochemical Features of High-Grade Serous Carcinoma of Ovary in Ascitic Fluid Effusion and Fine-Needle Aspiration Cytology.

American Journal of Clinical Pathology, 2020
OBJECTIVES High-grade serous carcinoma (HGSC) is the most common ovarian malignancy. The role of cytopathology in obtaining tissue diagnosis before institution of neoadjuvant chemotherapy (NACT) was evaluated.
Akriti Bansal, R. Srinivasan, M. Rohilla, A. Sundaram, B. Rai, A. Rajwanshi, V. Suri, S. Saha, N. Gupta, Parikshaa Gupta, P. Dey   +10 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Vogt-Koyanagi-Harada-Like Disease with Loss of Visual Acuity due to Sunitinib Treatment Restored after Switch in Therapy: A Case Report

Case Reports in Ophthalmology
Introduction: In this paper, we report a case of visual impairment during treatment with sunitinib in a patient with metastatic renal cell carcinoma. Methods: Retrospective chart review was used.
Mechteld C.S. van Olden, Yvonne de Jong-Hesse, Tessa Vollebregt, Stefanie de Groot, Saskia A.C. Luelmo, Marina Marinkovic   +5 more
doaj   +1 more source

A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy

Case Reports in Ophthalmology, 2019
The mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity ...
John R. Chancellor, David A. Kilgore, Ahmed B. Sallam, Richard C. Allen, Sami H. Uwaydat   +4 more
doaj   +1 more source

Validation of a Multivariate Serum Profile for Epithelial Ovarian Cancer Using a Prospective Multi-Site Collection [PDF]

, 2010
In previous studies we described the use of a retrospective collection of ovarian cancer and benign disease samples, in combination with a large set of multiplexed immunoassays and a multivariate pattern recognition algorithm, to develop an 11-biomarker ...
Beth Y. Karlan, Brian C. Mansfield, Brigitte E. Miller, Eva Chalas, Glenn E. Bigsby, Greg P. Bertenshaw, James F. Barter, James P. Mapes, James W. Orr, Jinghua Zhao, Katharine J. Bergstrom, Laurie L. Stephen, Lynda D. Roman, Michael E. McCollum, Partha Seshaiah, Paul A. DiSilvestro, Ping F. Yip, Robert W. Holloway, Ronald D. Alvarez, Suraj Amonkar, Tzong-Hao Chen   +20 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

INTRA VITREOUS BEVACIZUMAB VERSUS OBSERVATION IN ACUTE CENTRAL SEROUS CHORIORETINOPATHY.

Journal of University Medical & Dental College, 2018
: OBJECTIVE: To compare the efficacy of intravitreal bevacizumab for absorption of sub-retinal fluid in central serus chorio retinopathy from observation alone.
Bassam Mubarik , Ghulam Murtaza , Samra Naseem   +2 more
doaj  

Secondary open-angle glaucoma and serous macular detachment associated with pulmonary hypertension

American Journal of Ophthalmology Case Reports, 2020
Purpose: We describe a patient with secondary open-angle glaucoma and serous macular detachment associated with pulmonary hypertension. Observations: A 59 year-old male with pulmonary hypertension presented with vision loss and was noted to have ...
Isha Gupta, Luis Haddock, David S. Greenfield   +2 more
doaj   +1 more source