Results 51 to 60 of about 46,886 (295)

Measurement and Analysis of Serous Fluid in Central Serous Chorioretinopathy using OCT

Journal of the Korean Ophthalmological Society, 2008
Purpose: To evaluate the correlation between the degree of serous fluid and best corrected visual acuity at the first visit in central serous chorioretinopathy using optical coherence tomography. Methods: Retrospective analysis was performed for 30 eyes of 30 patients with central serous chorioretinopathy.
Sang Woong Moon, Joo-Hwa Lee, Hyuck-won Choi, Jae-Suk Kim   +3 more
openaire   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Micropulse laser for persistent optic disc pit maculopathy. A case report

American Journal of Ophthalmology Case Reports, 2018
Purpose: Optic disc pits (ODP) are rare and congenital anomalies of the optic disc, sometimes remaining asymptomatic. However, serous macular detachment or optic disc maculopathy is the most common complication, causing significant visual deterioration ...
Carlos Andrés Valdés-Lara, Nicolás Crim, Gerardo García-Aguirre, Ismael Ávila Lule, Virgilio Morales-Cantón   +4 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy

Case Reports in Ophthalmology, 2019
The mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity ...
John R. Chancellor, David A. Kilgore, Ahmed B. Sallam, Richard C. Allen, Sami H. Uwaydat   +4 more
doaj   +1 more source

Secondary open-angle glaucoma and serous macular detachment associated with pulmonary hypertension

American Journal of Ophthalmology Case Reports, 2020
Purpose: We describe a patient with secondary open-angle glaucoma and serous macular detachment associated with pulmonary hypertension. Observations: A 59 year-old male with pulmonary hypertension presented with vision loss and was noted to have ...
Isha Gupta, Luis Haddock, David S. Greenfield   +2 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Vogt-Koyanagi-Harada-Like Disease with Loss of Visual Acuity due to Sunitinib Treatment Restored after Switch in Therapy: A Case Report

Case Reports in Ophthalmology
Introduction: In this paper, we report a case of visual impairment during treatment with sunitinib in a patient with metastatic renal cell carcinoma. Methods: Retrospective chart review was used.
Mechteld C.S. van Olden, Yvonne de Jong-Hesse, Tessa Vollebregt, Stefanie de Groot, Saskia A.C. Luelmo, Marina Marinkovic   +5 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

INTRA VITREOUS BEVACIZUMAB VERSUS OBSERVATION IN ACUTE CENTRAL SEROUS CHORIORETINOPATHY.

Journal of University Medical & Dental College, 2018
: OBJECTIVE: To compare the efficacy of intravitreal bevacizumab for absorption of sub-retinal fluid in central serus chorio retinopathy from observation alone.
Bassam Mubarik , Ghulam Murtaza , Samra Naseem   +2 more
doaj