Results 181 to 190 of about 10,966 (204)

Protease inhibitor SERPINA1 expression in epithelial ovarian cancer

Clinical & Experimental Metastasis, 2010
Epithelial ovarian cancer is the most lethal gynecologic cancer with a 5 years survival rate of 30-40% in patients diagnosed with high-grade invasive disease (TOV). This is in stark contrast to the 95% 5 years survival rate in ovarian cancer patients diagnosed with low malignant potential (LMP) disease.
Karine, Normandin, Benjamin, Péant, Cécile, Le Page, Manon, de Ladurantaye, Véronique, Ouellet, Patricia N, Tonin, Diane M, Provencher, Anne-Marie, Mes-Masson   +7 more
openaire   +2 more sources

SERPINA1 and plasminogen as novel biomarkers in obstetric antiphospholipid syndrome patients

Clinical and Experimental Rheumatology, 2022
To explore the potential biomarkers and mechanisms in obstetric antiphospholipid syndrome (OAPS) patients by placental proteomics.Among 212 follow-up pregnancy patients based on the Chinese Rheumatism Data Center database (CRDC), we continuously recruited 30 pregnancy patients at the late stage of pregnancy for proteomics study. Fresh placental tissues
Zhijuan, Xie, Jiuliang, Zhao, Yijun, Song, Yin, Long, Can, Huang, Xinyan, Liu, Xinping, Tian, Mengtao, Li, Juntao, Liu, Xiaofeng, Zeng   +9 more
openaire   +2 more sources

Elevated expression of SerpinA1 and SerpinA3 in HLA‐positive cervical carcinoma

The Journal of Pathology, 2008
AbstractIn cervical cancer, an important mechanism by which tumour cells escape immune surveillance is loss of HLA class I, enabling tumours to evade recognition and lysis by cytotoxic T lymphocytes. Some tumours, however, escape from immune surveillance without accumulating defects in antigen presentation.
J N, Kloth, A, Gorter, G J, Fleuren, J, Oosting, S, Uljee, N, ter Haar, E J, Dreef, G G, Kenter, E S, Jordanova   +8 more
openaire   +2 more sources

Identification and characterisation of seven novel SERPINA1 null mutations

European Respiratory Journal, 2014
Background Alpha-1 antitrypsin (AAT) is a serine protease inhibitor, encoded by the highly polymorphic SERPINA1 gene. Mutations in this gene can lead to AAT deficiency (AATD) which is associated with a substantially increased risk of lung and liver disease. A group of rare
Ottaviani Stefania, Carroll Tomas P., Ferrarotti Ilaria, FRA, Annamaria, O'Brien Geraldine, Molloy Kevin, Corda Luciano, McElvaney Noel G., Luisetti Maurizio   +8 more
openaire   +2 more sources

Rare SERPINA1 allele Mwhitstable in patients with Alpha1-antitrypsin deficiency

Molecular pathology and funct. genomics, 2019
Background: Alpha1-Antitrypsin (AAT) Deficiency (AATD) is an hereditary disorder that may lead to early-onset emphysema, and chronic liver disease. AAT is a serine protease inhibitor, encoded by the highly polymorphic SERPINA1 gene (or PI system). PI*Mwhitstable is an intronic mutation consisting on 26-base pair (bp) deletion and 2-bp insertion in ...
Valentina Barzon, Alice Maria Balderacchi, Stefania Ottaviani, Angelo Giudo Corsico, Ilaria Ferrarotti   +4 more
openaire   +1 more source

SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.

Anticancer research, 2013
Through their roles in tissue remodeling, variants in the genes that encode alpha1-antitrypsin (AAT) and neutrophil elastase (NE) were hypothesized to be associated with the risk of both chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC).Cases with prevalent COPD (n=145), incident NSCLC (n=203) or prevalent COPD plus ...
Lindsey, Enewold, Leah E, Mechanic, Elise D, Bowman, Elizabeth A, Platz, Anthony J, Alberg   +4 more
openaire   +1 more source

Association Of SerpinA1 With Smoking And COPD

C40. COPD: ALPHA 1 ANTITRYPSIN, 2012
Anna Linja-Aho, Witold Mazur, Tuula Toljamo, Pentti Nieminen, Mikko Ronty, Steffen Ohlmeier, Vuokko L. Kinnula   +6 more
openaire   +1 more source

SERPINA1 as a therapeutic target in ATTR Amyloidosis

Zeitschrift für Gastroenterologie, 2018
C Niemietz, S Guttmann, V Sauer, A Zibert, H Schmidt   +4 more
openaire   +1 more source

Variants of SERPINA1 and the increasing complexity of testing for alpha-1 antitrypsin deficiency

Therapeutic Advances in Chronic Disease, 2021
Kimberly E Foil
exaly  

SERPINA1 wt Allele

2020
openaire   +1 more source