Results 161 to 170 of about 187,759 (346)

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Por que ser professor de filosofia? Alguns desafios

, 2008
Roberto Rondón
openalex   +2 more sources

Tornar-se residente aprendendo a ser adulto: necessidades na formação médica [PDF]

, 2020
Thiago Barros da Silva, Alexandre Brasil Carvalho da Fonseca   +1 more
openalex   +1 more source

Ser ou não ser?

, 2017
O crucial dilema proposto por Hamlet, discutido personagem do extraordinário Shakespeare, complementando por sua patética conclusão - EIS A QUESTÃO!
openaire   +1 more source

Ser hija, ser madre

, 2015
Maternidad, Mujer, Hijas, Madres La maternidad vista desde el punto de vista de ser hijas. Cómo se identifican las mujeres con su modelo de madre y cómo configuran su relación con otras mujeres y desarrollan su propia experiencia ...
openaire   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Development of a Magnetically-Assisted SERS Biosensor for Rapid Bacterial Detection

International Journal of Nanomedicine
Siyun Cheng,1,2,* Zhijie Tu,2,* Shuai Zheng,3 Adeel Khan,4 Ping Yang,1 Han Shen,1 Bing Gu2,3 1Department of Clinical Laboratory, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, People’s Republic
Cheng S, Tu Z, Zheng S, Khan A, Yang P, Shen H, Gu B   +6 more
doaj  

“A escola deveria ser afago pra gente”: ocupar e tornar a escola pública [PDF]

, 2020
Denise De Sordi, Douglas Gonsalves Fávero, Sérgio Paulo Morais   +2 more
openalex   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source