Results 281 to 290 of about 187,759 (346)

Tuning Surface-Enhanced Raman Scattering (SERS) via Filling Fraction and Period in Gold-Coated Bullseye Gratings. [PDF]

Nanomaterials (Basel)
Li Z, Cheng Y, Fernandes C, Wang X, Ruda HE.   +4 more
europepmc   +1 more source

Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón, Vahid Akbari, Ralph Rothstein, Alexandra Inman, Sanjiv Bhalla, Jianghong An, Jan M. Friedman, Rosanna Weksberg, Cornelius Boerkoel, Steven J. M. Jones, William T. Gibson   +10 more
wiley   +1 more source

Engineering Fluoroacetate Dehalogenase by Growth‐Based Selections on Non‐Natural Organofluorides

Angewandte Chemie, EarlyView.
We present a high‐throughput selection system to engineer fluoroacetate dehalogenases (FAcDs). By challenging E. coli populations that produce diverse FAcD libraries to grow on non‐natural organofluorides as their sole carbon source, we isolated a panel of FAcD variants with improved activity and altered substrate specificity.
Suzanne C. Jansen, Pauline van Beers, Clemens Mayer   +2 more
wiley   +2 more sources

Advances in measurable residual disease assessment for acute myeloid leukemia: from cytogenetics and molecular biology to assessment of the methylation pattern and surface-enhanced Raman scattering as emerging technologies. [PDF]

Biomark Res
Bancos A, Ivancuta A, Moisoiu V, Tigu AB, Gulei D, Nistor M, Moldovan CS, Kegyes D, Cenariu D, Zdrenghea M, Bojan A, Iancu SD, Leopold N, Ghiaur G, Bumbea H, Tanase A, Einsele H, Ciurea SO, Tomuleasa C.   +18 more
europepmc   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Blinking-Based Identification of Single Dye Molecules in Ink. [PDF]

Anal Chem
Khodabocus AJ, Knapp WT, Steinman BT, Knauss K, Stashenko J, McWeeney SL, Fitsum E, Autry C, Wustholz KL.   +8 more
europepmc   +1 more source

Review: Detection of Cancer Biomarkers from a Clinical Perspective. [PDF]

Int J Mol Sci
Terzapulo X, Dyussupova A, Ilyas A, Boranova A, Shevchenko Y, Mergenbayeva S, Kassenova A, Filchakova O, Gaipov A, Bukasov R.   +9 more
europepmc   +1 more source

Multiplexed Integrin Detection and Cancer Cell Classification Using Multicolor Gap-Enhanced Gold Nanorods and Machine Learning Algorithm. [PDF]

Nanomaterials (Basel)
Shah S, Youngerman R, Rodriguez-Nieves AL, Taylor ML, Bantom WR, Thompson D, Chen J, Wang Y, Huang X.   +8 more
europepmc   +1 more source

Portable and label-free optical detection of sweat glucose using functionalized plasmonic nanopillar array. [PDF]

Microsyst Nanoeng
Liu L, Zhan K, Kilpijärvi J, Kinnunen M, Zhao Y, Zhang Y, Yaltaye MW, Li Y, Zhyvolozhnyi A, Samoylenko A, Vainio S, Huang J.   +11 more
europepmc   +1 more source