Results 31 to 40 of about 193,735 (345)

Unlocking the future of environmental safety: a framework for integrating new approach methodologies in decision-making

NAM Journal
Traditional regulatory frameworks for assessing the environmental safety of chemicals have historically focused on evaluating in vivo data from standard ecologically representative species.
Claudia Rivetti, Jade Houghton, Maria Blanco Rubio, Danilo Basili, Predrag Kukic, Iris Muller, Geoff Hodges, Bruno Campos   +7 more
doaj   +1 more source

One-step preparation and characterization of core-shell SiO2/Ag composite spheres by pulse plating

Science and Engineering of Composite Materials, 2017
A simple method of one-step pulse plating was used in the fabrication of core-shell SiO2/Ag composite spheres. Structural characteristics and morphologies of the prepared SiO2/Ag composite spheres are characterized by means of X-ray diffraction, scanning
Xiong Li, Huang Xiangping, Liu Ya, Pan Liqing   +3 more
doaj   +1 more source

A characterization of four B16 murine melanoma cell sublines molecular fingerprint and proliferation behavior [PDF]

, 2013
Background: One of the most popular and versatile model of murine melanoma is by inoculating B16 cells in the syngeneic C57BL6J mouse strain. A characterization of different B16 modified cell sub-lines will be of real practical interest.
Barbu-Tudoran, Lucian, Bojin, Florina, Danciu, Corina, Dehelean, Cristina, Falamas, Alexandra, Munteanu, Melania F., Pînzaru, Simona Cîntă, Radeke, Heinfried Hermann, Soica, Codruţa   +8 more
core   +1 more source

Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety

Frontiers in Toxicology
IntroductionThis work evaluated a non-animal toolbox to be used within a next-generation risk assessment (NGRA) framework to assess chemical-induced lung effects using human upper and lower respiratory tract models, namely MucilAir™-HF and EpiAlveolar ...
Renato Ivan de Ávila, Iris Müller, Hugh Barlow, Alistair Mark Middleton, Mathura Theiventhran, Danilo Basili, Anthony M. Bowden, Ouarda Saib, Patrik Engi, Tymoteusz Pietrenko, Joanne Wallace, Bernadett Boda, Samuel Constant, Holger Peter Behrsing, Vivek Patel, Maria Teresa Baltazar   +15 more
doaj   +1 more source

Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions

Frontiers in Toxicology
New approach methodologies (NAMs) aim for animal-free chemical risk assessments. However, many in vitro NAM models still depend heavily on Matrigel and collagen despite the ethical, reproducibility, and biomedical concerns regarding the use of animal ...
Katharina S. Nitsche, Paul L. Carmichael, Paul L. Carmichael, Sophie Malcomber, Iris Müller, Hans Bouwmeester   +5 more
doaj   +1 more source

Label-free highly sensitive probe detection with novel hierarchical SERS substrates fabricated by nanoindentation and chemical reaction methods

Beilstein Journal of Nanotechnology, 2019
Nanostructures have been widely employed in surface-enhanced Raman scattering (SERS) substrates. Recently, in order to obtain a higher enhancement factor at a lower detection limit, hierarchical structures, including nanostructures and nanoparticles ...
Jingran Zhang, Tianqi Jia, Yongda Yan, Li Wang, Peng Miao, Yimin Han, Xinming Zhang, Guangfeng Shi, Yanquan Geng, Zhankun Weng, Daniel Laipple, Zuobin Wang   +11 more
doaj   +1 more source

Comparison of Free-Space and Waveguide-Based SERS Platforms

Nanomaterials, 2019
Surface-Enhanced Raman Spectroscopy (SERS) allows for the highly specific detection of molecules by enhancing the inherently weak Raman signals near the surface of plasmonic nanostructures.
Nina Turk, Ali Raza, Pieter Wuytens, Hans Demol, Michiel Van Daele, Christophe Detavernier, Andre Skirtach, Kris Gevaert, Roel Baets   +8 more
doaj   +1 more source

On the Measurements of the Surface-Enhanced Raman Scattering Spectrum: Effective Enhancement Factor, Optical Configuration, Spectral Distortion, and Baseline Variation

Nanomaterials, 2023
In this paper, a comprehensive theoretical framework for understanding surface-enhanced Raman scattering (SERS) measurements in both solution and thin-film setups, focusing on electromagnetic enhancement principles, was presented.
Yiping Zhao
doaj   +1 more source

Los años 60. Del ser o no ser al ser y no ser. [PDF]

Revista de Estudios Sociales, 2009
The 1960s have become the obligatory reference point to understand both general and particular social phenomenon. Since this period, and as a result of its new social practices (in the sense that there were no theories to explain them), new concepts and ways of speaking have arisen that, coming out of the acts and struggles of those years, are ...
  +6 more sources

Sensitivity analysis of the inputs for bioactivity-exposure ratio calculations in a NAM-based systemic safety toolbox

NAM Journal
To support regulatory decision-making without animal testing, Next-Generation Risk Assessment (NGRA) frameworks leverage New Approach Methodologies (NAM). A widely used strategy in such frameworks is to calculate Bioactivity-Exposure Ratios (BERs), which
Hsing-Chieh Lin, Maria T Baltazar, Sophie Cable, Lucie C. Ford, Alistair M Middleton, Beate Nicol, Ans Punt, Joe Reynolds, Ivan Rusyn, Weihsueh A Chiu   +9 more
doaj   +1 more source