Results 41 to 50 of about 33,675 (255)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Label-free highly sensitive probe detection with novel hierarchical SERS substrates fabricated by nanoindentation and chemical reaction methods

Beilstein Journal of Nanotechnology, 2019
Nanostructures have been widely employed in surface-enhanced Raman scattering (SERS) substrates. Recently, in order to obtain a higher enhancement factor at a lower detection limit, hierarchical structures, including nanostructures and nanoparticles ...
Jingran Zhang, Tianqi Jia, Yongda Yan, Li Wang, Peng Miao, Yimin Han, Xinming Zhang, Guangfeng Shi, Yanquan Geng, Zhankun Weng, Daniel Laipple, Zuobin Wang   +11 more
doaj   +1 more source

Plasmonic Mesoporous Composites as Molecular Sieves for SERS Detection [PDF]

, 2013
Application of surface-enhanced Raman scattering (SERS) spectroscopy to the ultrasensitive analysis of small molecules in biological samples is complicated by signal contamination by ubiquitous macromolecules such as proteins, nucleic acids, or lipids ...
Angelome, Paula Cecilia, Álvarez Puebla, Ramón, Liz-Marzán, Luis M., S. Abalde-Cela, R.A. Alvarez-Puebla, V. López-Puente, P.C. Angelomé, L.M. Liz-Marzán, López-Puente, Vanesa, Abalde-Cela, Sara   +9 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Sensitivity analysis of the inputs for bioactivity-exposure ratio calculations in a NAM-based systemic safety toolbox

NAM Journal
To support regulatory decision-making without animal testing, Next-Generation Risk Assessment (NGRA) frameworks leverage New Approach Methodologies (NAM). A widely used strategy in such frameworks is to calculate Bioactivity-Exposure Ratios (BERs), which
Hsing-Chieh Lin, Maria T Baltazar, Sophie Cable, Lucie C. Ford, Alistair M Middleton, Beate Nicol, Ans Punt, Joe Reynolds, Ivan Rusyn, Weihsueh A Chiu   +9 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Comparison of Free-Space and Waveguide-Based SERS Platforms

Nanomaterials, 2019
Surface-Enhanced Raman Spectroscopy (SERS) allows for the highly specific detection of molecules by enhancing the inherently weak Raman signals near the surface of plasmonic nanostructures.
Nina Turk, Ali Raza, Pieter Wuytens, Hans Demol, Michiel Van Daele, Christophe Detavernier, Andre Skirtach, Kris Gevaert, Roel Baets   +8 more
doaj   +1 more source

Ser finito y ser eterno / ser finito y ser mortal

Devenires, 2020
Como muchos otros filósofos y filósofas, Edith Stein dio cuenta de la recepción que tuvo en Alemania la obra fundamental de Martin Heidegger, Ser y Tiempo (1927). El impacto de esta obra fue enorme en el entorno filosófico alemán y, en particular, en el círculo fenomenológico de Friburgo. Edith Stein, formada al alero de Edmund Husserl, no es la
openaire   +1 more source

Interactions of single and few organic molecules with SERS hot spots investigated by orientational imaging and super-resolution optical imaging [PDF]

, 2013
textDynamics between organic molecules and surface enhanced Raman scattering (SERS) hot spots are extracted from far-field optical images by two experimental methods presented in this thesis: orientational imaging and super-resolution optical imaging. We
Stranahan, Sarah Marie
core  

Raman Chemical Imaging of Chromate Reduction Sites in a Single Bacterium Using Intracellularly Grown Gold Nanoislands [PDF]

, 2011
Imaging live molecular events within micro-organisms at single-cell resolution would deliver valuable mechanistic information much needed in understanding key biological processes. We present a surface-enhanced Raman (SERS) chemical imaging strategy as a
Ravindranath, Sandeep, Irudayaraj, J., Kristene L. Henne, Dorothea K. Thompson, Henne, K. L., Sandeep P. Ravindranath, Joseph Irudayaraj, Thompson, Dorothea, Irudayaraj, Joseph, Ravindranath, S. P., Thompson, D. K., Henne, Kristene L.   +11 more
core   +1 more source