Results 91 to 100 of about 1,156,944 (262)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus [PDF]

, 2008
High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial mediators of autoimmune diseases.
Wichmann, H. -Erich, Ursula Krämer, Liang Liming, Markus Ollert, Stephan Weidinger, Mempel, Martin, Bauer, Carl Peter, Baurecht Hansjörg, Prokisch Holger, Mehta Divya, von Berg, A., von Mutius, Erika, Bauer Carl Peter, Gohlke, H., Cookson, W., Depner, Martin, Wagenpfeil, S., Wichmann, H.-E., Illig, T., Michael Kabesch, Mempel, M., Novak, N., Mehta, D., Illig Thomas, Liang, L., Kabesch, Michael, von Berg Andrea, Moffatt Miriam, Prokisch, H., Heinrich Joachim, Herbarth, Olf, Gohlke Henning, Bieber, Thomas, Olf Herbarth, Martin Depner, Stefan Wagenpfeil, Heinrich, Joachim, H-Erich Wichmann, Erika von Mutius, Heinrich, J., Gieger, Christian, Heidrun Behrendt, Ollert Markus, Thomas Bieber, Meitinger, T., Divya Mehta, Ring, Johannes, Rodriguez Elke, Herbarth Olf, Miriam Moffatt, Natalija Novak, von Mutius Erika, Cookson William, Mehta, Divya, Behrendt Heidrun, Klopp, Norman, Ring Johannes, Bieber Thomas, Cookson, William, Sibylle Koletzko, Meitinger Thomas, Wichmann, Heinz-Erich, Mempel Martin, Hansjörg Baurecht, William Cookson, Kraemer, Ursula, Gieger, C., Gohlke, Henning, Christian Gieger, Baurecht, H., Depner Martin, Kabesch Michael, Weidinger, S., Bieber, T., Herbarth, O., Novak, Natalija, Berdel Dietrich, Moffatt, M., Berdel, D., von Mutius, E., Koletzko, Sibylle, Klopp, N., Krämer Ursula, Gieger Christian, Liang, Liming, Bauer, C.P., Johannes Ring, Berdel, Dietrich, Wagenpfeil, Stefan, Mutius, Erika von, Koletzko Sibylle, Koletzko, S., Rodriguez, E., Krämer, U., Ollert, Markus, Ollert, M., Rodriguez, Elke, Wichmann H.-Erich, Kabesch, M., Behrendt, H., Prokisch, Holger, Moffatt, Miriam, Henning Gohlke, Carl Peter Bauer, Illig, Thomas, Meitinger, Thomas, Liming Liang, Joachim Heinrich, Andrea von Berg, Thomas Illig, Novak Natalija, von Berg, Andrea, Weidinger, Stephan, Weidinger Stephan, Klopp Norman, Baurecht, Hansjoerg, Behrendt, Heidrun, Thomas Meitinger, Depner, M., Berg, Andrea von, Dietrich Berdel, Ring, J., Wagenpfeil Stefan, Elke Rodriguez, Norman Klopp, Martin Mempel, Holger Prokisch, Weidinger, S;Gieger, C;Rodriguez, E;Baurecht, H;Mempel, M;Klopp, N;Gohlke, H;Wagenpfeil, S;Ollert, M;Ring, J;Behrendt, H;Heinrich, J;Novak, N;Bieber, T;Kramer, U;Berdel, D;von Berg, A;Bauer, CP;Herbarth, O;Koletzko, S;Prokisch, H;Mehta, D;Meitinger, T;Depner, M;von Mutius, E;Liang, L;Moffatt, M;Cookson, W;Kabesch, M;Wichmann, HE;Illig, T   +127 more
core   +1 more source

Increasing incidence of serotype 38 invasive pneumococcal disease driven by the ST393 clone among children, Denmark 2022–2024

Scientific Reports
Non-vaccine-serotypes (non-VT) pose a challenge to reducing invasive pneumococcal disease (IPD). Since 2023, serotype 38 IPD has increased in Denmark promoting investigation of this serotype’s characteristics.
Christel Baagø Schjørring, Frederikke Kristensen Lomholt, Palle Valentiner-Branth, Tine Dalby, Kurt Fuursted, Hans-Christian Slotved, Zitta Barrella Harboe   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Increased serum levels of procollagen type III peptide in severely injured patients [PDF]

, 1993
Objectives: To determine the serum concentrations of procollagen type in peptide in severely injured patients with different outcomes and to evaluate the relationship between serum procollagen type III peptide concentrations, sources of increased ...
Waydhas, Christian, Trupka, Arnold, Nast-Kolb, Dieter, Schweiberer, Leonhard, Jochum, Marianne, Lenk, Susann, Duswald, Karl-Heimo   +6 more
core   +1 more source

Serum immunoreactive erythropoietin of children in health and disease [PDF]

, 1990
Serum immunoreactive erythropoietin (siEPO) was determined in cord serum from neonates (n = 97, gestational age 36-43 weeks), in healthy children from birth to adolescence (n = 260) and in children with haematological (n = 30), renal (n = 10) and ...
Pohlandt, F., Vetter, U., Kurtz, Armin, Hartmann, W., Eckardt, Kai-Uwe, Burghardt, R.   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Nucleosomes in serum of patients with early cerebral stroke [PDF]

, 2006
Background: Nucleosomes are cell death products that are elevated in serum of patients with diseases that are associated with massive cell destruction.
Geiger, Sandra, Holdenrieder, Stefan, Hamann, Gerhard F., Seidel, Dietrich, Ma, Jun, Brüning, Roland, Stieber, Petra, Nagel, Dorothea   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source