Results 111 to 120 of about 1,243,891 (211)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Increased serum levels of procollagen type III peptide in severely injured patients [PDF]

, 1993
Objectives: To determine the serum concentrations of procollagen type in peptide in severely injured patients with different outcomes and to evaluate the relationship between serum procollagen type III peptide concentrations, sources of increased ...
Waydhas, Christian, Trupka, Arnold, Nast-Kolb, Dieter, Schweiberer, Leonhard, Jochum, Marianne, Lenk, Susann, Duswald, Karl-Heimo   +6 more
core   +1 more source

Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children. [PDF]

, 2011
Tracking of fatty acid (FA) contribution to plasma or serum lipids over time was shown in children and adults. However, the potential role of FADS gene variants has not been investigated.
Demmelmair Hans, Berthold Koletzko, Rzehak, P., Claudia Glaser, Peter Rzehak, Joachim Heinrich, Heinrich, Joachim, Glaser, C., Glaser, Claudia, Heinrich, J., LISA study group, Klopp Norman, Demmelmair, Hans, Klopp, N., Rzehak, Peter, Demmelmair, H., Koletzko Berthold, Rzehak Peter, Glaser Claudia, LISAplus Study Group (Wichmann, H.-E. ; Heinrich, J. ; Bolte, G. ; Belcredi, P. ; Jacob, B. ; Schoetzau, A. ; Mosetter, M. ; Schindler, J. ; Höhnke, A.), Hans Demmelmair, null null, Norman Klopp, Heinrich Joachim, Koletzko, Berthold, Klopp, Norman, Koletzko, B., Glaser, C;Rzehak, P;Demmelmair, H;Klopp, N;Heinrich, J;Koletzko, B   +27 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis

Scientific Reports, 2017
In the absence of a validated correlate of protection or robust animal models for human tuberculosis, Mycobacterial growth inhibition assays (MGIAs) aim to assess vaccines ability to inhibit mycobacterial growth in-vitro.
Christina Jensen, Line Lindebo Holm, Erik Svensson, Claus Aagaard, Morten Ruhwald   +4 more
doaj   +1 more source

Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum

Microbial Cell Factories, 2018
Background The production of recombinant proteins with proper conformation, appropriate post-translational modifications in an easily scalable and cost-effective system is challenging.
Susheel K. Singh, Régis Wendpayangde Tiendrebeogo, Bishwanath Kumar Chourasia, Ikhlaq Hussain Kana, Subhash Singh, Michael Theisen   +5 more
doaj   +1 more source

Nucleosomes in serum of patients with early cerebral stroke [PDF]

, 2006
Background: Nucleosomes are cell death products that are elevated in serum of patients with diseases that are associated with massive cell destruction.
Geiger, Sandra, Holdenrieder, Stefan, Hamann, Gerhard F., Seidel, Dietrich, Ma, Jun, Brüning, Roland, Stieber, Petra, Nagel, Dorothea   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Design of hepadnavirus core protein-based chimeric virus-like particles carrying epitopes from respiratory syncytial virus

npj Vaccines
Respiratory syncytial virus (RSV) is one of the most important pathogens causing respiratory tract infection in humans, especially in infants and the elderly. The identification and structural resolution of the potent neutralizing epitopes on RSV fusion (
Shuai Shao, Xue Feng Zhang, Jun Wei Hou, Sen Sen Yang, Zi Bo Han, Hai Lan Wu, Fang Tang, Xin Yu Li, Ze Hua Lei, Zi Xin Zhao, Shu Xiang Li, Zhao Ming Liu, Pu Shan, Yu Qin Jin, Ji Guo Su, Yu Liang, Jing Zhang, Qi Ming Li   +17 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source