Results 91 to 100 of about 275,854 (308)

RAGE Signaling in Skeletal Biology [PDF]

, 2019
PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M., Essex, Alyson L., Plotkin, Lilian I.   +2 more
core   +2 more sources

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Association of results of the glutaraldehyde coagulation test with plasma acute phase protein concentrations and hematologic findings in hospitalized cows

Frontiers in Veterinary Science
IntroductionThe glutaraldehyde test (GAT) allows for animal-side semi-quantitative estimation of fibrinogen and gamma-globulin concentrations in blood samples of adult cattle and therefore detection of inflammatory disease conditions.
Florian M. Trefz, Florian M. Trefz, Martina Balmer, Laureen M. Peters, Rupert M. Bruckmaier, Mireille Meylan   +5 more
doaj   +1 more source

New markers of bulk milk quality in relation to mastitis [PDF]

, 2009
All dairy processors depend on a continuous supply of high-quality bulk milk from milk producers to be able to distribute liquid milk and dairy products.
Wickström, Erik
core  

Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier [PDF]

, 2016
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-beta (A beta) brain accumulation and drives ...
Alessandro Di Spiezio, Axel Heimann, Bell, Bouter, Bu, Carsten Korth, Claus U. Pietrzik, Deane, Deane, Dodart, Hahn, Heyser, Ingrid Prikulis, Ito, Ito, Ito, Julius N. Meißner, Julius Nahrath, Kanekiyo, Korth, Leneuve, Markus Schwaninger, Mc Donald, Nils Schubert, Qosa, Roosmarijn E. Vandenbroucke, Sabrina Meister, Sandra Baches, Sascha Weggen, Steffen E. Storck, Thomas A. Bayer, Tooyama, Tooyama, Wolf, Yvonne Bouter   +34 more
core   +2 more sources

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Tracheobronchial amyloidosis following COVID‐19 infection

Respirology Case Reports
Deposition of amyloid proteins in extracellular space can occur due to uncontrolled inflammatory processes. Tracheobronchial amyloidosis (TBA) is a rare form of such disease.
Chathurangi Angammana, Sameera Gamlath, Ravini Karunathilake, Shehan Silva   +3 more
doaj   +1 more source

Crystal structure of monomeric human β-2- microglobulin reveals clues to its amyloidogenic properties [PDF]

, 2002
Dissociation of human β-2-microglobulin (β(2)m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from this protein.
A. P. Kalverda, Adams, Becker, Bellotti, Berman, Booth, C. H. Trinh, Collaborative Computational Project Number, Connors, D. P. Smith, Delaglio, Esposito, Floege, Hoshino, Kabsch, Kad, Khan, Khurana, Laskowski, Linke, McParland, Merritt, Morgan, Ohhashi, Okon, Richardson, S. E. Radford, S. E. V. Phillips, Saper, Smith, Verdone, Wang   +31 more
core   +2 more sources

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, EarlyView.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source

Comparison of Serum Amyloid A Measurements in Equine Synovial Fluid With Routine Diagnostic Methods to Detect Synovial Infection in a Clinical Environment

Frontiers in Veterinary Science, 2019
Synovial fluid analysis is utilized to diagnose septic synovitis. However, not all cases are clearly and rapidly discernible with the diagnostic tools available in the laboratory.
John David Stack, Matthieu Cousty, Emma Steele, Ian Handel, Antoine Lechartier, Tatiana Vinardell, Tatiana Vinardell, Florent David, Florent David   +8 more
doaj   +1 more source