Results 131 to 140 of about 275,854 (308)

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

Application of serum levels of SAA,CysC,ACR and IL-19 in the diagnosis of type 2 diabetic nephropathy

Linchuang shenzangbing zazhi, 2021
Objective To explore the diagnostic values of serum amyloid A（SAA）,Cystatin C（CysC）,albumin-to-creatinine ratio（ACR）and interleukin-19（IL-19）for type 2 diabetic nephropathy（DN）.Methods From October 2017 to October 2020,a total of 108 type 2 diabetics ...
Cui Juan, Chen Lian-lian, Ma Ying, Li Ting, Cheng Cun-xiang, Xiao Gai-e   +5 more
doaj  

Coincident Fluorescence‐Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles From Human Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen, Aleksandr Barulin, Won Jong Yu, Jong‐Chan Park, Inki Kim   +4 more
wiley   +1 more source

Haptoglobin and serum amyloid a in subacute ruminal acidosis in goats

Revista de la Facultad de Medicina Veterinaria y de Zootecnia, 2010
Ruminal acidosis is a frequent disorder that occurs in goats as a consequence of feedingmistakes in animals not adapted to a diet of easily fermentable carbohydrates.
F.H.D. González, F.H. Ruipérez, J.M. Sánchez, J.C. Souza, S. Martínez-Subiela, J.J. Cerón   +5 more
doaj  

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Successful treatment of AA amyloidosis with tocilizumab, resulting in the disappearance of amyloid deposits: a case-based review

Egyptian Rheumatology and Rehabilitation
Background AA amyloidosis is a multisystem disease characterized by the deposition of serum amyloid A protein, which is secondary to chronic inflammation.
Marina Tortosa-Cabañas, José Acosta Batlle, Cristian Perna, Javier Bachiller-Corral   +3 more
doaj   +1 more source

Serum amyloid a protein as a potential biomarker in predicting acute onset and association with in-hospital death in acute aortic dissection

BMC Cardiovascular Disorders, 2019
Background Acute aortic dissection (AAD) is a life-threatening disorder in vascular surgery with a high early mortality. Serum amyloid A (SAA) is a kind of acute-phase protein with a rapid diagnostic value in other diseases.
Yuchen He, Changcheng Ma, Jia Xing, Shiyue Wang, Chao Ji, Yanshuo Han, Jian Zhang   +6 more
doaj   +1 more source

Practical Application of Urinary Zearalenone Monitoring System for Feed Hygiene Management of a Japanese Black Cattle Breeding Herd—The Relationship between Monthly Anti-Müllerian Hormone and Serum Amyloid A Concentrations [PDF]

, 2022
Oky Setyo Widodo, Makoto Etoh, Emiko Kokushi, Seiichi Uno, Osamu Yamato, Dhidhi Pambudi, Hiroaki Okawa, Masayasu Taniguchi, Mirni Lamid, Mitsuhiro Takagi   +9 more
openalex   +1 more source

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, EarlyView.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source