Results 111 to 120 of about 3,759,142 (392)

Dietary calcium intake, serum calcium level, and their association with preeclampsia in rural North India

Indian Journal of Community Medicine, 2016
Background: Preeclampsia in pregnancy has been shown to be associated with low serum calcium level. Though the evidence is abundant, it is equivocal.
Anant Gupta, Shashi Kant, Chandrakant S Pandav, Sanjeev K Gupta, Sanjay K Rai, Puneet Misra   +5 more
doaj   +1 more source

Serum biomarkers of the calcium-deficient rats identified by metabolomics based on UPLC/Q-TOF MS/MS

Nutrition & Metabolism, 2020
Background We previously identified the urinary biomarkers to diagnose calcium deficiency and nutritional rickets by ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS/MS).
Fanyu Meng, Lina Fan, Lin Sun, Qingli Yu, Maoqing Wang, Changhao Sun   +5 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of Feeding a Calcium Chloride Supplement on Sow Stillbirth Rate

Animals
The present study was undertaken to determine the effect of daily calcium chloride (CaCl2) supplementation from day of entry into the farrowing house until day of farrowing (6.4 ± 0.3 d) on stillbirth rates.
Sahara Craig, Si-En Ruth Khaw, Kiro R. Petrovski, Roy N. Kirkwood   +3 more
doaj   +1 more source

Serum phosphorus and calcium levels, and kidney disease progression in immunoglobulin A nephropathy [PDF]

, 2021
Guizhen Yu, Junhao Cheng, Yan Jiang, Heng Li, Xiayu Li, Jianghua Chen   +5 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Serum Calcium Levels in Preterm and Term Neonates on Phototherapy

, 2014
Introduction: In addition to known causes of hypocalcemia like, prematurity, Intrauterine growth retardation (IUGR), asphyxia, sepsis, infants of diabetic mothers (IDM), high phosphate formula, Magnesium deficiency, effect of phototherapy on serum ...
Sunita Arora, G. S. Narang, Gurmeet Singh   +2 more
semanticscholar   +1 more source

Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

PLoS Genetics, 2013
Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown.
C. O’Seaghdha, Hongsheng Wu, Qiong Yang, K. Kapur, I. Guessous, A. M. Zuber, A. Köttgen, Candice Stoudmann, A. Teumer, Z. Kutalik, M. Mangino, A. Dehghan, Weihua Zhang, G. Eiriksdottir, Guo Li, Toshiko Tanaka, L. Portas, Lorna M. Lopez, C. Hayward, K. Lohman, K. Matsuda, S. Padmanabhan, D. Firsov, R. Sorice, Sheila Ulivi, A. Brockhaus, M. Kleber, A. Mahajan, F. Ernst, V. Gudnason, L. Launer, A. Macé, Eric Boerwinckle, D. Arking, C. Tanikawa, Yusuke Nakamura, Morris J. Brown, J. Gaspoz, J. Theler, D. Siscovick, B. Psaty, S. Bergmann, P. Vollenweider, V. Vitart, A. Wright, T. Zemunik, M. Boban, I. Kolčić, P. Navarro, E. Brown, K. Estrada, Jingzhong Ding, T. Harris, S. Bandinelli, D. Hernandez, A. Singleton, G. Girotto, D. Ruggiero, A. d’Adamo, A. Robino, T. Meitinger, C. Meisinger, G. Davies, J. Starr, J. Chambers, B. Boehm, B. Winkelmann, Jie Huang, F. Murgia, S. Wild, H. Campbell, A. Morris, O. Franco, A. Hofman, A. Uitterlinden, F. Rivadeneira, U. Völker, A. Hannemann, R. Biffar, W. Hoffmann, So-Youn Shin, P. Lescuyer, Hughes Henry, C. Schurmann, P. Munroe, P. Gasparini, N. Pirastu, M. Ciullo, C. Gieger, W. März, L. Lind, T. Spector, A. Smith, I. Rudan, James F. Wilson, O. Polašek, I. Deary, M. Pirastu, L. Ferrucci, Yongmei Liu, B. Kestenbaum, J. Kooner, J. Witteman, M. Nauck, W. Kao, H. Wallaschofski, O. Bonny, C. Fox, M. Bochud   +108 more
semanticscholar   +1 more source