Results 131 to 140 of about 2,046,062 (298)

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Serum ferritin levels and risk of gestational diabetes mellitus: A cohort study

Scientific Reports
Gestational diabetes mellitus (GDM) is a glucose metabolism disorder with an unclear etiology that occurs specifically during pregnancy. While elevated serum ferritin levels have been reported to increase the risk of GDM, these findings lack validation ...
Yupei Xie, Siyu Dai, Qian Chen, Dan Shan, Xiongfei Pan, Yayi Hu   +5 more
doaj   +1 more source

Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: The aim of this study is to evaluate serum ferritin levels and polycystic ovary syndrome (PCOS)-related complications in obese and nonobese women. Materials and methods: This retrospective study included 539 (286 with PCOS and 253 without PCOS)
Po-Chun Ko, Shih-Yi Huang, Ching-Hung Hsieh, Ming-I Hsu, Chun-Sen Hsu   +4 more
doaj   +1 more source

Serum Ferritin Levels Correlation With Heart and Liver MRI and LIC in Patients With Transfusion-Dependent Thalassemia

Iranian Red Crescent Medical Journal, 2015
Background: Iron-loaded cardiac complication is the essential cause of mortality in patients with thalassemia. Early detection and treatment of cardiac over-load can reduce mortality.
Zahra Majd, S. Haghpanah, G. Ajami, S. Matin, H. Namazi, Marzieh Bardestani, M. Karimi   +6 more
semanticscholar   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

A Radioimmunoassay for Serum Ferritin

Clinical Chemistry, 1977
Abstract We describe the development and evaluation of a serum ferritin radioimmunoassay, in which 125l-labeled ferritin and rabbit anti-ferritin antibody are used. Goat anti-rabbit gamma-globulin antibody, together with polyethylene glycol, is used as the separating reagent.
A W, Luxton, W H, Walker, J, Gauldie, A M, Ali, C, Pelletier   +4 more
openaire   +2 more sources

A Prussian Blue Nanozyme‐Adjuvanted Vaccine Presenting Phosphocholine Antigens for Induction of Immunotolerance in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study developed a novel nano‐vaccine (Ferritin‐PC@PBNZs) comprising a ferritin‐based scaffold for the multivalent display of phosphorylcholine (PC) antigens, integrated with Prussian blue nanozymes (PBNZs) as a potent adjuvant. By leveraging the ferritin carrier for high‐density and ordered antigen display, the nano‐vaccine significantly augments ...
Jingyi Sheng, Yubo Huang, Xinyue Li, Yin Liu, Yuehuang Wu, Yuxin Zhang, Ning Gu   +6 more
wiley   +1 more source

Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study. [PDF]

, 2020
BackgroundFew cross-sectional studies report iron deficiency (ID) prevalence in women of different race/ethnicity and ages in US or Canada.Materials and methodsWe evaluated screening observations on women who participated between 2001-2003 in a cross ...
Acton, Ronald T, Adams, Paul C, Barton, James C, Eckfeldt, John H, Gordeuk, Victor R, Harris, Emily L, Harrison, Helen, McLaren, Christine E, McLaren, Gordon D, Reboussin, David M, Wiener, Howard H   +10 more
core  

Defining serum ferritin thresholds to predict clinically relevant liver iron concentrations for guiding deferasirox therapy when MRI is unavailable in patients with non‐transfusion‐dependent thalassaemia

British Journal of Haematology, 2015
Liver iron concentration (LIC) assessment by magnetic resonance imaging (MRI) remains the gold standard to diagnose iron overload and guide iron chelation therapy in patients with non‐transfusion‐dependent thalassaemia (NTDT).
A. Taher, J. Porter, V. Viprakasit, A. Kattamis, S. Chuncharunee, P. Sutcharitchan, N. Siritanaratkul, R. Origa, Z. Karakaş, D. Habr, Zewen Zhu, M. Cappellini   +11 more
semanticscholar   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source