Results 201 to 210 of about 124,117 (258)

Retrospective neutralization analysis of SARS-CoV-2 variants in early pandemic sera. [PDF]

Front Immunol
Mahdi M, Al-Muffti AS, Linkner TR, Miltner N, Misák O, Várkonyi I, Tőzsér J.   +6 more
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition. [PDF]

PLoS Pathog
Myers A, Chandravanshi M, Whitmore LS, Kohrn BF, Negash A, Nguyen DN, Ralli-Jain P, Cruickshank K, Upadhyay AA, Charles T, Edwards CT, Hunter E, Amara RR, Korzeniowski MK, Niu L, Pozharski E, Tolbert WD, Bosinger SE, Kennedy SR, Pazgier M, Derdeyn CA.   +20 more
europepmc   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Retooling a novel influenza B hemagglutinin to redirect neutralizing antibodies against B/Victoria strains. [PDF]

Vaccine
Carlock MA, Ross TM.
europepmc   +1 more source

Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis

Advanced Science, EarlyView.
ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu, Chang‐geng Xu, Xiao‐wei Hu, Run‐run Shan, Jia‐nan Wang, Xiang‐yu Li, Yu‐qing Wang, Yu‐hang Dong, Shen‐Zhuo‐Fan Huang, Shuai Sun, Tian Zhao, Ya‐Xin Ru, Xiao‐yu Shen, Rui Hou, Jian‐min You, Fei Zhang, Chao Li, Jie Wei, Chao Hou, Zhi‐juan Wang, Dan‐feng Zhang, Juan Jin, Jia‐gen Wen, Yu‐jie Liu, Ming‐ming Liu, Xiao‐ming Meng, Wei Wang   +26 more
wiley   +1 more source

Potent neutralization and therapeutic efficacy of bovine rotavirus-specific VHH antibodies in infected calves. [PDF]

Vet Res
Zhao Q, Gao M, Li P, Wang B, Li B, Rile G, Du C, Wang J, Wang H, Mei J, Zhang S, Bao F.   +11 more
europepmc   +1 more source

Convergent evolution of the N156K mutation in A(H1N1)pdm09 hemagglutinin contributes to antigenic drift and cluster transition. [PDF]

Emerg Microbes Infect
Tian Y, Jiang D, Ma W, Nie J, Li Q, Zhao C, Xu S, Huang W, Wang Y.   +8 more
europepmc   +1 more source

Evaluation of candidate reference materials for the harmonization of Lassa fever serology. [PDF]

Emerg Microbes Infect
Bentley EM, Ithete N, Mitchell J, Richardson SAS, Bernasconi V, Killip M, Garry RF, Branco L, Günther S, Atkinson E, Rigsby P, Hinrichs M, Oestereich L, Thielebein A, Omoifo V, Omiunu R, Esumeh R, Okogbenin S, Kristiansen PA, Page M, Ogbaini-Emovon E, Mattiuzzo G, Collaborative Study Participants.   +22 more
europepmc   +1 more source

Serological response to feline coronavirus in the UK domestic cat population. [PDF]

J Gen Virol
Sasvari H, Sherry L, Logan N, Dunbar D, Tyson GB, Tait-Burkard C, Weir W, Willett BJ, Hosie MJ.   +8 more
europepmc   +1 more source