Results 41 to 50 of about 124,117 (258)
Microbiology Spectrum, 2023 Rising breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4/5 led to the performance of various studies investigating systemic immunity and neutralizing antibodies in sera, but mucosal immunity remains ...
Gabriel Diem +7 more
doaj +1 more source
Booster COVID-19 vaccination against the SARS-CoV-2 Omicron variant: A systematic review
Human Vaccines & Immunotherapeutics, 2022 There is a wealth of data suggesting that the effectiveness of existing vaccines against the Omicron variant, the most mutated SARS-CoV-2 variant to date, has been substantially reduced if only primary vaccination is administered.
Yuxuan Du, Long Chen, Yuan Shi
doaj +1 more source
Vaccines, 2022 Hemodialysis patients are exposed to a markedly increased risk when infected with SARS-CoV-2. To date, it is unclear if hemodialysis patients benefit from four vaccinations.
Cho-Chin Cheng +18 more
doaj +1 more source
Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma
International Journal of Molecular Sciences, 2023 Alterations of sphingolipids and their metabolizing enzymes play a role in various diseases. However, peripheral biomarkers for such changes are limited. Particularly, in the increasingly reported involvement of neutral sphingomyelinase (NSM) with four described isoforms in tissues or cells, a peripheral marker is lacking.
Christiane Mühle, Johannes Kornhuber
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Ciência Rural, 2000 A detecção de anticorpos anti-Herpesvírus Bovino tipo 1 (BHV-1) foi realizada, através da técnica de soroneutralização, em 1235 amostras de soro de bovinos adultos, não-vacinados contra Rinotraqueíte Infecciosa Bovina.
Kerlei Cristina Médici +2 more
doaj +1 more source
Serum Neutralization of Distemper Virus in Chick Embryos.
Experimental Biology and Medicine, 1954 SummaryVirus-neutralization tests were carried out in embryonated hen's eggs employing the egg-adapted distemper virus and various samples of serum. Ferrets whose sera contained no demonstrable antibody at 1:40 dilution all succumbed to 100 MLD of ferret distemper virus, whereas ferrets showing antibody titer to 1:640 dilution of serum all survived the
D T, IMAGAWA +3 more
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Hexons from adenovirus serotypes 5 and 48 differentially protect adenovirus vectors from neutralization by mouse and human serum. [PDF]
PLoS ONE, 2018 Adenovirus vectors are widely used in gene therapy clinical trials, and preclinical studies with these vectors are often conducted in mice. It is therefore critical to understand whether mouse studies adequately predict the behavior of adenovirus vectors
Andrew W Harmon +3 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source