Results 21 to 30 of about 1,253 (206)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Prevalence of Autoantibodies (ACPA) and Rheumatoid Factor among Rheumatoid Arthritis Patients in Sulaymaniyah

Advanced Medical Journal
Background and objectives: Rheumatoid factor and anticitrullinated protein antibodies are the most characteristic autoantibodies for rheumatoid arthritis.
Zhwan Ebrahem Muhillddin, Raouf Rahim Merza   +1 more
doaj   +1 more source

A comparative study on serum lipoprotein (a) and lipid profile between rheumatoid arthritis patients and normal subjects

Journal of Pharmacy and Bioallied Sciences, 2015
Background: Rheumatoid arthritis is a chronic and systemic inflammatory disorder, in which Lipoprotein (a) [Lp (a)] increases plaque formation and thus promotes atherosclerosis.
K P Shiva Govindan, Saleem Basha, V Ramesh, C Naveen Kumar, S Swathi   +4 more
doaj   +1 more source

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Influence of Vitamin D Deficiency on Rheumatoid Arthritis Course

Bolʹ, Sustavy, Pozvonočnik, 2016
The article deals with the influence of vitamin D deficiency on the course of rheumatoid arthritis. It encloses the review and the results of own researches. It was found that 54.9 % of the patients with rheumatoid arthritis had vitamin D deficiency, and
V.V. Povoroznyuk, O.V. Sinenky
doaj   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Investigation of the Mechanism of Action of Periploca forrestii Schltr. Extract on Adjuvant Collagen Rats Based on UPLC-Q-Orbitrap-HRMS Non-Targeted Lipidomics

Molecules, 2023
Periploca forrestii Schltr. (P. forrestii) is a classical medicinal plant and is commonly used in traditional medicine for the treatment of rheumatoid arthritis, soft tissue injuries, and traumatic injuries. The aim of this study was to evaluate the anti-
Silan An, Xiaoting Yan, Huaguo Chen, Xin Zhou   +3 more
doaj   +1 more source

A study of IgG-rheumatoid factor in the serum of patients with rheumatoid arthritis.

Japanese Journal of Clinical Immunology, 1993
酵素免疫測定法によるIgG-RF測定キットED 001を用いて,慢性関節リウマチ(RA)および各種疾患患者血清中のIgG-RFを測定した. RAでのIgG-RF陽性率は25.5% (24/94)で,シェーグレン症候群を除く他の膠原病患者群に比較して高値であった. RAにおいては, X-ray stage, ADL classが進むにつれてIgG-RFが高くなる傾向がみられた.またIgG-RFとLansbury活動性指数,関節点数,握力,赤沈, IgM-RF, CRPやTNF-αなどとの間に相関が認められた.またIgG-RFと血清中遊離型ICAM-1値との間に有意な相関を認め,さらにアレルギー性肉芽腫性血管炎の2例にIgG-RFの高値が認められたことより, IgG-RFと血管炎との関連性が示唆された.
Aoki, Shigeo, Imai, Kohzoh, Yamamura, Miyuki, Tsujisaki, Masayuki, Sugiyama, Toshiroh, Hinoda, Yuji, Nagao, Masato, Ishii, Seiichi, Yachi, Akira   +8 more
openaire   +2 more sources