Results 111 to 120 of about 1,006,166 (271)
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response
Advanced Science, EarlyView.This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du +10 more
wiley +1 more source
Labour Supply Response to Spousal Sickness Absence [PDF]
This study examines labour supply responses to spousal sickness absence (SSA) using a Swedish longitudinal panel data, from 1996-2002. The overall results present an evidence of a decrease in labour supply in response to spousal sickness absence.
Nahum, Ruth-Aïda
core
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Interaction of job disamenities, job satisfaction, and sickness absences: Evidence from a representative sample of Finnish workers [PDF]
This paper explores the potential role of adverse working conditions in the determination of workers’ sickness absences. Our data contain detailed information on the prevalence of job disamenities at the workplace from a representative sample of Finnish ...
Böckerman, Petri, Ilmakunnas, Pekka
core
Psychosocial factors and work related sickness absence among permanent and non-permanent employees [PDF]
, 2004 Study objective: To examine the association between psychosocial work factors and work related sickness absence among permanent and non-permanent employees by sex.Design: A cross sectional survey conducted in 2000 of a representative sample of the ...
Benavides, FG +4 more
core
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
Serum Sickness/Serum Sickness-like Reactions Following Ocrelizumab Infusion in 2 Patients With Multiple Sclerosis. [PDF]
Int J MS Care, 2023 Rjeily NB, Nourbakhsh B, Mowry EM.
europepmc +1 more source
BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer
Advanced Science, EarlyView.BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu +12 more
wiley +1 more source
A comparison of self-reported sickness absence with absences recorded in employers' registers: evidence from the Whitehall II study [PDF]
, 2005 Aim: To compare self-reported sickness absence days in the last 12 months with recorded absences from the employers' registers for the same period.Methods: Self-reported sickness absence data over the 12 months preceding baseline ( 1985 - 88) were ...
Kivimaki, M +5 more
core