Results 1 to 10 of about 21,866,651 (305)

SARS-CoV-2 antibodies recognize 23 distinct epitopic sites on the receptor binding domain

Communications Biology, 2023
The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions.
Jiansheng Jiang, Christopher T. Boughter, Javeed Ahmad, Kannan Natarajan, Lisa F. Boyd, Martin Meier-Schellersheim, David H. Margulies   +6 more
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Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways

Scientific Data, 2022
Measurement(s) molecules per cell Technology Type(s) nanoflow high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry Sample Characteristic - Organism Mus ...
Nathan P. Manes, Jessica M. Calzola, Pauline R. Kaplan, Iain D. C. Fraser, Ronald N. Germain, Martin Meier-Schellersheim, Aleksandra Nita-Lazar   +6 more
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Myristoylated, alanine-rich C-kinase substrate (MARCKS) regulates toll-like receptor 4 signaling in macrophages

Scientific Reports, 2023
MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation.
Jiraphorn Issara-Amphorn, Virginie H. Sjoelund, Margery Smelkinson, Sebastian Montalvo, Sung Hwan Yoon, Nathan P. Manes, Aleksandra Nita-Lazar   +6 more
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Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation

Nature Communications, 2022
The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide ...
Jiansheng Jiang, Daniel K. Taylor, Ellen J. Kim, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Hau V. Truong, Claire H. Woodward, Nikolaos G. Sgourakis, Peter Cresswell, David H. Margulies, Kannan Natarajan   +11 more
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Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

Cell Reports, 2022
Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John, Anju Singh, Jing Sun, Makheni Jean Pierre, Lulwah Alsalih, Crystal Lipsey, Ziann Traore, Shenavia Balcom-Luker, Clinton J. Bradfield, Jian Song, Tovah E. Markowitz, Margery Smelkinson, Marc Ferrer, Iain D.C. Fraser   +13 more
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OMiCC: An expanded and enhanced platform for meta-analysis of public gene expression data

STAR Protocols, 2022
Summary: OMiCC (OMics Compendia Commons) is a biologist-friendly web platform that facilitates data reuse and integration. Users can search over 40,000 publicly available gene expression studies, annotate and curate samples, and perform meta-analysis ...
Candace C. Liu, Yongjian Guo, Kiera L. Vrindten, William W. Lau, Rachel Sparks, John S. Tsang   +5 more
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Normalizing and denoising protein expression data from droplet-based single cell profiling

Nature Communications, 2022
Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.
Matthew P. Mulè, Andrew J. Martins, John S. Tsang   +2 more
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The Road Less Taken: Less Appreciated Pathways for Manipulating CD8+ T Cell Exhaustion

Frontiers in Immunology, 2022
Exhausted CD8+ T (Tex) cells are a distinct cell population that arise during persistent antigen exposure in the context of chronic infections and cancers.
Andrea C. Pichler, Jennifer L. Cannons, Pamela L. Schwartzberg, Pamela L. Schwartzberg   +3 more
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Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions

eLife, 2023
T cells are critically important components of the adaptive immune system primarily responsible for identifying and responding to pathogenic challenges.
Christopher T Boughter, Martin Meier-Schellersheim   +1 more
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Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways

mSystems, 2021
Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models ...
Nathan P. Manes, Aleksandra Nita-Lazar
doaj   +1 more source