Results 1 to 10 of about 20,768,159 (307)

Human Plasma-like Medium Improves T Lymphocyte Activation

iScience, 2020
Summary: T lymphocytes are critical for effective immunity, and the ability to study their behavior in vitro can facilitate major insights into their development, function, and fate.
Michael A. Leney-Greene, Arun K. Boddapati, Helen C. Su, Jason R. Cantor, Michael J. Lenardo   +4 more
doaj   +1 more source

The Canadian collaborative project on genetic susceptibility to multiple sclerosis cohort population structure and disease etiology

Frontiers in Neurology
BackgroundPrevious genetic and epidemiological studies have examined subpopulations from the Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis (CCPGSMS) patient cohort, but an encompassing analysis of the study population has
Alison M. Pagalilauan, Alison M. Pagalilauan, Elif Everest, Elif Everest, Suzanna Rachimi, Suzanna Rachimi, Daniel S. Reich, Alex D. Waldman, Alex D. Waldman, Alex D. Waldman, A. Dessa Sadovnick, A. Dessa Sadovnick, Carles Vilarino-Guell, Michael J. Lenardo, Michael J. Lenardo   +14 more
doaj   +1 more source

Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA

Nature Communications
The immunologic consequences of using bactericidal versus bacteriostatic antibiotic treatments are unclear. We observed a bacteriostatic (growth halting) treatment was more protective than a bactericidal (bacteria killing) treatment in a murine ...
Julia L. Gross, Rahul Basu, Clinton J. Bradfield, Jing Sun, Sinu P. John, Sanchita Das, John P. Dekker, David S. Weiss, Iain D. C. Fraser   +8 more
doaj   +1 more source

Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis

Cell Reports
Summary: The pair of transcription factors Bcl6-Blimp1 is well known for follicular T helper (Tfh) early cell fate determination; however, the mechanism(s) for late regulation of CXCR5 during Tfh migration into germinal centers (GCs) is still unclear. In
Xiaoliang Zhu, Xi Chen, Yaqiang Cao, Chengyu Liu, Zoey J. Kline, Gangqing Hu, Sundar Ganesan, Tibor Z. Veres, Difeng Fang, Shuai Liu, Danping Wei, Hirofumi Shibata, Dominic P. Golec, Hyunwoo Chung, Ronald N. Germain, Pamela L. Schwartzberg, Keji Zhao, Jinfang Zhu   +17 more
doaj   +1 more source

The Abnormal CD4+T Lymphocyte Subset Distribution and Vbeta Repertoire in New-onset Rheumatoid Arthritis Can Be Modulated by Methotrexate Treament

Cells, 2019
Patients with long-term, treated, rheumatoid arthritis (RA) show abnormalities in their circulating CD4+ T-lymphocytes, but whether this occurs in recently diagnosed naïve patients to disease-modifying drugs (DMARDs) is under discussion.
Jorge Monserrat, Cristina Bohórquez, Ana María Gómez Lahoz, Atusa Movasat, Ana Pérez, Lucía Ruíz, David Díaz, Luis Chara, Ana Isabel Sánchez, Fernando Albarrán, Ignacio Sanz, Melchor Álvarez-Mon   +11 more
doaj   +1 more source

Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models

EMBO Molecular Medicine, 2019
PARN, poly(A)‐specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated with Høyeraal–Hreidarsson (HH) syndrome, a rare telomere biology ...
Maname Benyelles, Harikleia Episkopou, Marie‐Françoise O'Donohue, Laëtitia Kermasson, Pierre Frange, Florian Poulain, Fatma Burcu Belen, Meltem Polat, Christine Bole‐Feysot, Francina Langa‐Vives, Pierre‐Emmanuel Gleizes, Jean‐Pierre de Villartay, Isabelle Callebaut, Anabelle Decottignies, Patrick Revy   +14 more
doaj   +1 more source

Glucocorticoid use as a cause of non-cellular immune response to SARS-Cov2 Spike in patients with immune system diseases. [PDF]

J Autoimmun, 2022
Renaudineau Y, Sailler L, Abravanel F, Izopet J, Delourme A, Biotti D, Ciron J, Treiner E, Congy-Jolivet N, Bost C, Blancher A.   +10 more
europepmc   +1 more source

Disturbed Systemic Immune Balance in Periodontal Disease

Autoimmunity, 1998
To the editorSir; Human periodontitis is a disease caused by some bacterial infections. In etiopathogene-sis, the role of disturbed local and systemic immunoregulatory mechanisms have drawn the attention. Down-regulation of local T-suppressor cells was commented as the cause of enhanced local immunoglobulin production (1).
Karaarslan, F, Coker, I, Kumru, G, Caglayan, S   +3 more
openaire   +2 more sources

Multiple Sclerosis is Not a Disease of the Immune System

The Quarterly Review of Biology, 2011
Multiple sclerosis is a complex neurodegenerative disease, thought to arise through autoimmunity against antigens of the central nervous system. The autoimmunity hypothesis fails to explain why genetic and environmental risk factors linked to the disease in one population tend to be unimportant in other populations.
openaire   +3 more sources

Overview of the Immune System and Immunodeficiency Diseases

Veterinary Clinics of North America: Small Animal Practice, 1994
The principal role of the immune system is the protection of the host against invasion by infectious disease agents and other substances considered foreign to the host. The term "immunity" refers to all the mechanisms that the body uses to protect itself against environmental antigens. This article gives an overview of the immune system and its defense
openaire   +2 more sources