Results 31 to 40 of about 1,197,933 (265)
Lentivirus-mediated Conditional Gene Expression
Bio-Protocol, 2021 The ability to identify the role of a particular gene within a system is dependent on control of the expression of that gene. In this protocol, we describe a method for stable, conditional expression of Nod-Like receptors (NLRs) in THP-1 cells using a ...
Leah Rommereim +4 more
doaj +1 more source
The role of the immune system in kidney disease [PDF]
Clinical and Experimental Immunology, 2018 Summary The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease.
Tecklenborg, Josefine +3 more
openaire +3 more sources
Crosstalk between ILC2s and Th2 cells varies among mouse models
Cell Reports, 2023 Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are still
Rama K. Gurram +14 more
doaj +1 more source
Immune System Response in Alzheimer's Disease [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1989 ABSTRACT:Involvement of the immune system in the pathogenesis of Alzheimer's disease was demonstrated in two ways: by the attachment of complement proteins to diseased tissue, and by the activation of cells associated with the immune system. Alzheimer brain tissue was stained immunohistochemically by antibodies to components of the classical, but not ...
P L, McGeer +3 more
openaire +2 more sources
A new immune disease: systemic hypertension
Clinical Kidney Journal, 2023 ABSTRACT Systemic hypertension is the most common medical comorbidity affecting the adult population globally, with multiple associated outcomes including cerebrovascular diseases, cardiovascular diseases, vascular calcification, chronic kidney disease, metabolic syndrome and mortality.
Sidar Copur +4 more
openaire +2 more sources
Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells
Scientific Reports, 2021 MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4+ T helper cells which are key players in autoimmune diseases.
Anju Singh +13 more
doaj +1 more source
Hodgkin Disease and the Role of the Immune System [PDF]
Pediatric Hematology and Oncology, 2011 Hodgkin disease (HD) is a malignancy of primarily B lymphocytes that has the unique ability to cause immunodeficiency, as well as provide immune evasion mechanisms to avoid self-destruction. In this review, the authors discuss Hodgkin disease, its association with Epstein-Barr virus (EBV), the immune deficiency caused by HD, and tumor immune evasion ...
Alana A, Kennedy-Nasser +2 more
openaire +2 more sources
Prion Disease and the Innate Immune System [PDF]
Viruses, 2012 Prion diseases or transmissible spongiform encephalopathies are a unique category of infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by misfolding of the cellular prion protein these disorders possess an infectious quality that thrives in immune-competent hosts.
Barry Bradford, Neil Mabbott
openaire +4 more sources
The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling
Frontiers in Immunology, 2018 Antigen presentation is a cellular process that involves a number of steps, beginning with the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides to cellular compartments where they are loaded on MHC class I (MHC-I ...
Kannan Natarajan +8 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko +19 more
wiley +1 more source