Results 31 to 40 of about 1,192,654 (265)
IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses
eLife, 2019 Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined.
Rachel A Gottschalk +10 more
doaj +1 more source
Frontiers in Immunology, 2023 Foxp3 is regarded as the major transcription factor for T regulatory (Treg) cells and expression of Foxp3 is used to identify and quantitate Treg cells in mouse models.
Lyra Morina +9 more
doaj +1 more source
The innate immune system in demyelinating disease [PDF]
Immunological Reviews, 2012 Summary: Demyelinating diseases such as multiple sclerosis are chronic inflammatory autoimmune diseases with a heterogeneous clinical presentation and course. Both the adaptive and the innate immune systems have been suggested to contribute to their pathogenesis and recovery. In this review, we discuss the role of the innate immune system in mediating
Lior, Mayo +2 more
openaire +2 more sources
LPS Tolerance Inhibits Cellular Respiration and Induces Global Changes in the Macrophage Secretome
Biomolecules, 2021 Inflammatory response plays an essential role in the resolution of infections. However, inflammation can be detrimental to an organism and cause irreparable damage.
Joseph Gillen +7 more
doaj +1 more source
DNA, the Immune System, and Atopic Disease [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2004 The prevalence and severity of atopic diseases (atopic dermatitis, asthma, and allergic rhinitis) have increased over recent decades, particularly in industrialized nations. Atopic dermatitis, like asthma, is more common in older siblings and in less crowded houses and with late entry to day care, increased maternal education, and higher socio-economic
Hussain, Iftikhar, Kline, Joel N.
openaire +2 more sources
GATA3 induces the pathogenicity of Th17 cells via regulating GM-CSF expression
Frontiers in Immunology, 2023 T-bet-expressing Th17 (T-bet+RORγt+) cells are associated with the induction of pathology during experimental autoimmune encephalomyelitis (EAE) and the encephalitic nature of these Th17 cells can be explained by their ability to produce GM-CSF. However,
Matthew J. Butcher +8 more
doaj +1 more source
Regulation of Macrophage Polarization in Allergy by Noncoding RNAs
Non-Coding RNA, 2023 Allergy is a type 2 immune reaction triggered by antigens known as allergens, including food and environmental substances such as peanuts, plant pollen, fungal spores, and the feces and debris of mites and insects.
Osamu Ishibashi +2 more
doaj +1 more source
mSystems, 2017 The bodies of mammals are hosts to vast microbial communities composed of trillions of bacteria from thousands of species, whose effects on health and development have begun to be appreciated only recently.
Nathan P. Manes +5 more
doaj +1 more source
Immune System Response in Alzheimer's Disease [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1989 ABSTRACT:Involvement of the immune system in the pathogenesis of Alzheimer's disease was demonstrated in two ways: by the attachment of complement proteins to diseased tissue, and by the activation of cells associated with the immune system. Alzheimer brain tissue was stained immunohistochemically by antibodies to components of the classical, but not ...
P L, McGeer +3 more
openaire +2 more sources
Biomedicines, 2021 Objective: To describe the capacity of a broad spectrum of cytokines and growth factors to predict ICU admission and/or death in patients with severe COVID-19.
Jorge Monserrat +16 more
doaj +1 more source