Results 11 to 20 of about 4,063,072 (347)

The role of platelets in immune-mediated inflammatory diseases

Nature Reviews Immunology, 2023
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and uncontrolled inflammation and thrombosis, both of which are responsible for organ damage, morbidity and death.
M. Scherlinger, C. Richez, G. Tsokos, É. Boilard, P. Blanco   +4 more
semanticscholar   +3 more sources

Metabolic regulation of the immune system in health and diseases: mechanisms and interventions

Signal Transduction and Targeted Therapy
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells.
Tengyue Hu, Changhai Liu, Min Lei, Qingmin Zeng, Li Li, Hong Tang, Nannan Zhang   +6 more
semanticscholar   +3 more sources

Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation

Nature Communications, 2022
The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide ...
Jiansheng Jiang, Daniel K. Taylor, Ellen J. Kim, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Hau V. Truong, Claire H. Woodward, Nikolaos G. Sgourakis, Peter Cresswell, David H. Margulies, Kannan Natarajan   +11 more
doaj   +1 more source

Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

Cell Reports, 2022
Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John, Anju Singh, Jing Sun, Makheni Jean Pierre, Lulwah Alsalih, Crystal Lipsey, Ziann Traore, Shenavia Balcom-Luker, Clinton J. Bradfield, Jian Song, Tovah E. Markowitz, Margery Smelkinson, Marc Ferrer, Iain D.C. Fraser   +13 more
doaj   +1 more source

Immune System Response in Alzheimer's Disease [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1989
ABSTRACT:Involvement of the immune system in the pathogenesis of Alzheimer's disease was demonstrated in two ways: by the attachment of complement proteins to diseased tissue, and by the activation of cells associated with the immune system. Alzheimer brain tissue was stained immunohistochemically by antibodies to components of the classical, but not ...
P L, McGeer, H, Akiyama, S, Itagaki, E G, McGeer   +3 more
openaire   +2 more sources

A new immune disease: systemic hypertension

Clinical Kidney Journal, 2023
ABSTRACT Systemic hypertension is the most common medical comorbidity affecting the adult population globally, with multiple associated outcomes including cerebrovascular diseases, cardiovascular diseases, vascular calcification, chronic kidney disease, metabolic syndrome and mortality.
Sidar Copur, Ibrahim B Peltek, Ali Mutlu, Cem Tanriover, Mehmet Kanbay   +4 more
openaire   +2 more sources

OMiCC: An expanded and enhanced platform for meta-analysis of public gene expression data

STAR Protocols, 2022
Summary: OMiCC (OMics Compendia Commons) is a biologist-friendly web platform that facilitates data reuse and integration. Users can search over 40,000 publicly available gene expression studies, annotate and curate samples, and perform meta-analysis ...
Candace C. Liu, Yongjian Guo, Kiera L. Vrindten, William W. Lau, Rachel Sparks, John S. Tsang   +5 more
doaj   +1 more source

Normalizing and denoising protein expression data from droplet-based single cell profiling

Nature Communications, 2022
Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.
Matthew P. Mulè, Andrew J. Martins, John S. Tsang   +2 more
doaj   +1 more source

The Road Less Taken: Less Appreciated Pathways for Manipulating CD8+ T Cell Exhaustion

Frontiers in Immunology, 2022
Exhausted CD8+ T (Tex) cells are a distinct cell population that arise during persistent antigen exposure in the context of chronic infections and cancers.
Andrea C. Pichler, Jennifer L. Cannons, Pamela L. Schwartzberg, Pamela L. Schwartzberg   +3 more
doaj   +1 more source

Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions

eLife, 2023
T cells are critically important components of the adaptive immune system primarily responsible for identifying and responding to pathogenic challenges.
Christopher T Boughter, Martin Meier-Schellersheim   +1 more
doaj   +1 more source