Results 51 to 60 of about 4,063,072 (347)

Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]

, 2017
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello, Mazzone, Roberta, Valente, Sergio, Zwergel, Clemens   +3 more
core   +1 more source

Disturbed Systemic Immune Balance in Periodontal Disease

Autoimmunity, 1998
To the editorSir; Human periodontitis is a disease caused by some bacterial infections. In etiopathogene-sis, the role of disturbed local and systemic immunoregulatory mechanisms have drawn the attention. Down-regulation of local T-suppressor cells was commented as the cause of enhanced local immunoglobulin production (1).
Karaarslan, F, Coker, I, Kumru, G, Caglayan, S   +3 more
openaire   +2 more sources

Correlations in the T Cell Response to Altered Peptide Ligands

, 2004
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases.
Arstila, Bachmann, Bachmann, Blattman, Bogarad, Chandler, Deem, Derrida, Derrida, Drossel, Garboczi, Garcia, Jeong-Man Park, Kauffman, Kedl, Kesmir, Klenerman, Lee, Lee, Martin, Michael W. Deem, Perelson, Perelson, Schodin, Singh, Sloan-Lancaster, Sourdive   +26 more
core   +1 more source

Virological aspects of Epstein-Barr virus infections. [PDF]

, 2005
Epstein-Barr virus (EBV) is usually maintained in an asymptomatic and latent form by the host immune system, and primarily by EBV-specific cytotoxic T cells (CTLs).
Kimura, Hiroshi, Morishima, Tsuneo, Yamashita, Nobuko   +2 more
core   +1 more source

The Impact of Immune System Aging on Infectious Diseases

Microorganisms
Immune system aging is becoming a field of increasing public health interest because of prolonged life expectancy, which is not paralleled by an increase in health expectancy.
Eugenia Quiros-Roldan, A. Sottini, Pier Giorgio Natali, L. Imberti   +3 more
semanticscholar   +1 more source

The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases

Frontiers in Immunology, 2016
Analogous to other physiological systems, the immune system also demonstrates remarkable sex differences. Although the reasons for sex differences in immune responses are not precisely understood, it potentially involves differences in sex hormones ...
H. Waldmann, S. Ahmed, D. Khan
semanticscholar   +1 more source

Bifidobacteria-mediated immune system imprinting early in life

bioRxiv, 2020
Immune-microbe interactions early in life influence an individual’s risk of developing allergies, asthma and some autoimmune disorders. Breastfeeding helps guide the development of healthy immune-microbe relationships, in part by providing nutrients to ...
B. Henrick, L. Rodriguez, T. Lakshmikanth, Christian Pou, E. Henckel, E. Henckel, E. Henckel, Axel Olin, Jun Wang, J. Mikeš, Ziyang Tan, Yang Chen, Amy M. Ehrlich, A. Bernhardsson, C. Mugabo, Ylva Ambrosiani, A. Gustafsson, A. Gustafsson, Stephanie Chew, H. Brown, Johann Prambs, Kajsa Bohlin, Kajsa Bohlin, Ryan D. Mitchell, M. Underwood, J. Smilowitz, J. German, S. Frese, P. Brodin, P. Brodin   +29 more
semanticscholar   +1 more source

The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling

Frontiers in Immunology, 2018
Antigen presentation is a cellular process that involves a number of steps, beginning with the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides to cellular compartments where they are loaded on MHC class I (MHC-I ...
Kannan Natarajan, Jiansheng Jiang, Nathan A. May, Michael G. Mage, Lisa F. Boyd, Andrew C. McShan, Nikolaos G. Sgourakis, Ad Bax, David H. Margulies   +8 more
doaj   +1 more source

Type 2 Diabetes and its Impact on the Immune System

Current Diabetes Reviews, 2020
Introduction: Type 2 Diabetes (T2D) is a major health problem worldwide. This metabolic disease is indicated by high blood glucose levels due to insufficient insulin production by the pancreas.
Afiat Berbudi, N. Rahmadika, Adi Tjahjadi, R. Ruslami   +3 more
semanticscholar   +1 more source

RANKL biology: bone metabolism, the immune system, and beyond

Inflammation and Regeneration, 2020
Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts.
Takehito Ono, M. Hayashi, Fumiyuki Sasaki, T. Nakashima   +3 more
semanticscholar   +1 more source