Results 61 to 70 of about 1,192,654 (265)

Recovery of Capsaicinoids and Other Phytochemicals Involved With TRPV-1 Receptor to Re-valorize Chili Pepper Waste and Produce Nutraceuticals

Frontiers in Sustainable Food Systems, 2021
The hot chili pepper industry represents one of the most important staple foods in Mexico and many Asian countries. Nowadays, large amounts of waste materials are produced from the pepper supply chain that could be used as a source to obtain ...
Hector Emmanuel Cortés-Ferré, Daniel Guajardo-Flores, Gregorio Romero-De La Vega, Janet Alejandra Gutierrez-Uribe, Janet Alejandra Gutierrez-Uribe   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PARP Inhibition Shifts Murine Myeloid Cells Toward a More Tolerogenic Profile In Vivo

Biomolecules
The human Poly ADP-ribose Polymerase (PARP) family comprises 17 enzymes responsible for the transfer of ADP-ribose to proteins, forming poly- or mono-ADP-ribosylation.
Jose R. Pittaluga-Villarreal, Casey M. Daniels, Tara Capece, Pauline R. Kaplan, Martin Meier-Schellersheim, Aleksandra Nita-Lazar   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural mechanism of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity

Communications Biology
Anti-major histocompatibility complex class I (MHC-I) mAbs can stimulate immune responses to tumors and infections by blocking suppressive signals delivered via various immune inhibitory receptors.
Jiansheng Jiang, Abir K. Panda, Kannan Natarajan, Haotian Lei, Shikha Sharma, Lisa F. Boyd, Reanne R. Towler, Sruthi Chempati, Javeed Ahmad, Abraham J. Morton, Zabrina C. Lang, Yi Sun, Nikolaos Sgourakis, Martin Meier-Schellersheim, Rick K. Huang, Ethan M. Shevach, David H. Margulies   +16 more
doaj   +1 more source

Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l

Stem Cell Reports, 2015
Members of the miR-290 family are the most abundantly expressed microRNAs (miRNAs) in mouse embryonic stem cells (ESCs). They regulate aspects of differentiation, pluripotency, and proliferation of ESCs, but the molecular program that they control has ...
Chryssa Kanellopoulou, Timothy Gilpatrick, Gokhul Kilaru, Patrick Burr, Cuong K. Nguyen, Aaron Morawski, Michael J. Lenardo, Stefan A. Muljo   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Off-Label Use of Antineoplastics in Oncology Is Limited But Has Notable Scientific Support in a University Hospital Setting

Frontiers in Pharmacology, 2019
Purpose: The off-label (OL) use of antineoplastic drugs for the treatment of various types of tumors in patients of different disease stages is becoming a common occurrence.
Marta Herrero Fernandez, Raquel Molina Villaverde, Raquel Molina Villaverde, Raquel Molina Villaverde, Monica Arroyo Yustos, Monica Arroyo Yustos, Monica Arroyo Yustos, Fatima Navarro Expósito, Fatima Navarro Expósito, Fatima Navarro Expósito, Jose Luis Lopez Gonzalez, Jose Luis Lopez Gonzalez, Jose Luis Lopez Gonzalez, Maria Rosario Luque Infantes, Melchor Alvarez-Mon Soto, Melchor Alvarez-Mon Soto, Melchor Alvarez-Mon Soto   +16 more
doaj   +1 more source

A syndrome featuring developmental disorder of the nervous system induced by a novel mutation in the TCF20 gene, rarely concurrent immune disorders: a case report

Frontiers in Genetics, 2023
Background: The expression of TCF20 is the most widespread in brain tissue. TCF20 depletion or mutation can affect the proliferation and differentiation of embryonic neurons, leading to developmental disorder of the central nervous system and subsequent ...
Si Huang, Si Huang, Si Huang, Si Huang, Jiaxin Xu, Yiyang Li, Wenhui Mo, Xiuwen Lin, Yajun Wang, Yajun Wang, Yajun Wang, Fujian Liang, Yan Bai, Guochun Huang, Jing Chen, Jing Xin, Guoda Ma, Guoda Ma, Guoda Ma   +18 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source