Results 81 to 90 of about 21,866,651 (305)

Associations between selected immune-mediated diseases and tuberculosis: record-linkage studies. [PDF]

, 2013
BACKGROUND: Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS: We analyzed a database of linked statistical records of hospital admissions and death certificates ...
Michael J Goldacre, Goldacre, R, Sreeram V Ramagopalan, Conlon, C, Raph Goldacre, Andrew Skingsley, Ramagopalan, SV, Skingsley, A, Goldacre, MJ, Chris Conlon   +9 more
core   +2 more sources

The Canadian collaborative project on genetic susceptibility to multiple sclerosis cohort population structure and disease etiology

Frontiers in Neurology
BackgroundPrevious genetic and epidemiological studies have examined subpopulations from the Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis (CCPGSMS) patient cohort, but an encompassing analysis of the study population has
Alison M. Pagalilauan, Alison M. Pagalilauan, Elif Everest, Elif Everest, Suzanna Rachimi, Suzanna Rachimi, Daniel S. Reich, Alex D. Waldman, Alex D. Waldman, Alex D. Waldman, A. Dessa Sadovnick, A. Dessa Sadovnick, Carles Vilarino-Guell, Michael J. Lenardo, Michael J. Lenardo   +14 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Circular RNAs in Immune-Related Diseases

CircRNAs are a novel class of noncoding RNAs characterized by a covalently closed loop structure lacking both a 3' polyadenylation tail and a 5' cap.
Floris, Matteo, Idda, Maria Laura, Fara, Antonella Francesca   +2 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

An artificial immune system for clustering amino acids in the context of protein function classification [PDF]

, 2009
This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon, Clark, Edward, Flower, Darren R., Secker, Andrew D., Davies, Matthew N., Freitas, Alex A.   +5 more
core   +1 more source

Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA

Nature Communications
The immunologic consequences of using bactericidal versus bacteriostatic antibiotic treatments are unclear. We observed a bacteriostatic (growth halting) treatment was more protective than a bactericidal (bacteria killing) treatment in a murine ...
Julia L. Gross, Rahul Basu, Clinton J. Bradfield, Jing Sun, Sinu P. John, Sanchita Das, John P. Dekker, David S. Weiss, Iain D. C. Fraser   +8 more
doaj   +1 more source

Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis

Cell Reports
Summary: The pair of transcription factors Bcl6-Blimp1 is well known for follicular T helper (Tfh) early cell fate determination; however, the mechanism(s) for late regulation of CXCR5 during Tfh migration into germinal centers (GCs) is still unclear. In
Xiaoliang Zhu, Xi Chen, Yaqiang Cao, Chengyu Liu, Zoey J. Kline, Gangqing Hu, Sundar Ganesan, Tibor Z. Veres, Difeng Fang, Shuai Liu, Danping Wei, Hirofumi Shibata, Dominic P. Golec, Hyunwoo Chung, Ronald N. Germain, Pamela L. Schwartzberg, Keji Zhao, Jinfang Zhu   +17 more
doaj   +1 more source

The Abnormal CD4+T Lymphocyte Subset Distribution and Vbeta Repertoire in New-onset Rheumatoid Arthritis Can Be Modulated by Methotrexate Treament

Cells, 2019
Patients with long-term, treated, rheumatoid arthritis (RA) show abnormalities in their circulating CD4+ T-lymphocytes, but whether this occurs in recently diagnosed naïve patients to disease-modifying drugs (DMARDs) is under discussion.
Jorge Monserrat, Cristina Bohórquez, Ana María Gómez Lahoz, Atusa Movasat, Ana Pérez, Lucía Ruíz, David Díaz, Luis Chara, Ana Isabel Sánchez, Fernando Albarrán, Ignacio Sanz, Melchor Álvarez-Mon   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source