Results 201 to 210 of about 1,892,741 (310)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

High dietary protein and energy content does not alter hepatic and renal health blood markers in growing lambs. [PDF]

Trop Anim Health Prod
Cairo FC, Souza Lima CL, Carvalho Matos S, Silva MP, Dos Santos GR, Pereira Neto E, Ribas Santos MP, Silva Mariz LD, Pereira ES, Gomes Azevedo JA, Pinto de Carvalho GG, Santos Pina DD, Santos SA.   +12 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Effect of percutaneous acupoint electrical stimulation combined with nutritional support on gastrointestinal function and nutritional status of patients after unicondylar knee arthroplasty. [PDF]

Front Nutr
Liu J, Wang X, Fang Q, Yang Y, Wang P, Zhao Y.   +5 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Calculus Bovis ameliorates primary sclerosing cholangitis via a dual-pronged mechanism restoring bile acid and lipid homeostasis in the gut-liver axis. [PDF]

Chin Med
Gong X, Chen Y, Zhao T, Li N, Yang G, Qiu L, Yu Z, Liu D, Xiang D.   +8 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Impact of COVID-19 Booster Vaccination on Serum Redox Homeostasis. [PDF]

Int J Mol Sci
Vukčević M, Spasić DM, Kešelj V, Platanić Arizanović L, Grahovac T, Vidonja Uzelac T, Oreščanin Dušić Z, Nikolić-Kokić A, Nikolić M.   +8 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Longitudinal CSF and Serum Biomarker Dynamics in Tofersen-Treated <i>SOD1</i>-ALS: A Real-World Multicentre Cohort Study. [PDF]

Int J Mol Sci
Giordano A, Mandrioli J, Cerri F, Lunetta C, Saebfar H, Catania M, Battipaglia C, Leone L, Trojsi F, Vizziello M, Gerardi F, Farè M, Zulueta A, Piras R, Giacchino M, Gianferrari G, Dalla Bella E, Domi T, Bonanomi D, Ganci G, Lombardi R, Lauria G, Riva N.   +22 more
europepmc   +1 more source