Results 141 to 150 of about 77,106 (306)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Multilevel Effects of Principals' Servant Leadership on Kindergarten Teachers' Job Crafting: The Mediating Role of Organizational Identification. [PDF]

Behav Sci (Basel)
Lin X, Jiao R, Li F.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

servant

, 1974
servant [S] 1 [S] nHe came out here as a servant for the Hudson's Bay Company.PRINTED ITEM DNE-citG.M.Story JUN 1974 JH JUN 1974Used I and SupUsed I and SupNot usedFISHERY SERVANT, FISHING ~ .

core  

The impact of group-based arts activity participation on community residents' psychological well-being: the roles of emotional intelligence and servant organizers. [PDF]

BMC Psychol
Ran Y, Feng Y.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

servant

, 1980
servant [S] 1 [S] nMaybe re-think sense 2. See CARTWRIGHT Gloss PlanterYes, revision suggested in Ed file slip.SEP 26 1980Used I and SupUsed I and SupNot usedFISHERY SERVANT, FISHING ~ . Cp DIETER, wages-servant, summer servants, servant passengers,

core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

How does servant leadership affect unethical pro-organizational behaviors: examining a moderated mediation model. [PDF]

BMC Psychol
Gül E, Timuroglu MK.
europepmc   +1 more source

Servant Leadership, Innovativeness, and Servant Performance

This study aims to examine and analyzes the effect of servant leadership on servant performance and innovativeness. Besides, the impact of servant leadership on innovativeness is also checked and analyzed. Moreover, to attain this goal, this study applies the servants from one of the churches in Bandung: Gereja Kristen Kemah Daud, as a population ...
Ana Mariana, Bram Hadianto, Catherine Suyanto, Asian Institute of Research   +3 more
openaire   +1 more source