Results 101 to 110 of about 779,994 (339)

GPS e Internet per fare la "differenza"

GEOmedia, 2016
GPS ed Internet per fare la "differenza"
Fabrizio Bernardini
doaj  

BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra

Nucleic Acids Res., 2018
Circular dichroism (CD) spectroscopy is a widely used method to study the protein secondary structure. However, for decades, the general opinion was that the correct estimation of β-sheet content is challenging because of the large spectral and ...
András Micsonai, F. Wien, Éva Bulyáki, J. Kun, Éva Moussong, Young-Ho Lee, Y. Goto, M. Réfrégiers, J. Kardos   +8 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

psRNATarget: a plant small RNA target analysis server (2017 release)

Nucleic Acids Res., 2018
Plant regulatory small RNAs (sRNAs), which include most microRNAs (miRNAs) and a subset of small interfering RNAs (siRNAs), such as the phased siRNAs (phasiRNAs), play important roles in regulating gene expression.
X. Dai, Zhaohong Zhuang, P. Zhao
semanticscholar   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

LBS avanzati su dispositivi PDA II° parte

GEOmedia, 2014
LBS avanzati su dispositivi PDA II ...
Francesco Bartoli, Fabrizio Bernardini
doaj  

HawkDock: a web server to predict and analyze the protein–protein complex based on computational docking and MM/GBSA

Nucleic Acids Res., 2019
Protein–protein interactions (PPIs) play an important role in the different functions of cells, but accurate prediction of the three-dimensional structures for PPIs is still a notoriously difficult task.
Gaoqi Weng, Ercheng Wang, Zhe Wang, Hui Liu, Feng Zhu, Dan Li, Tingjun Hou   +6 more
semanticscholar   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

HDOCK: a web server for protein–protein and protein–DNA/RNA docking based on a hybrid strategy

Nucleic Acids Res., 2017
Protein–protein and protein–DNA/RNA interactions play a fundamental role in a variety of biological processes. Determining the complex structures of these interactions is valuable, in which molecular docking has played an important role. To automatically
Yumeng Yan, Di Zhang, Pei-Zhang Zhou, Botong Li, Shengyou Huang   +4 more
semanticscholar   +1 more source