Results 121 to 130 of about 314,651 (267)

Computational Design of an mRNA Vaccine Targeting LRP6 for Triple-Negative Breast Cancer Therapy. [PDF]

Cancer Rep (Hoboken)
Teimoori P, Heidari M.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

PolyProline Predictor: A web server for empirical sequence-based prediction of polyproline II helices. [PDF]

Protein Sci
López-Sánchez R, Pantoja-Uceda D, Mompeán M, Laurents DV.   +3 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Joint optimization of task offloading and energy trading in edge-enabled smart grids using deep reinforcement learning. [PDF]

PLoS One
Xue R, Li B, He W, Wang Y.
europepmc   +1 more source

Maize’s origin to be revisited

Plant Signaling & Behavior
Khaled Moustafa
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

LiraSearch-ultrafast ligand shape and electrostatic matching server. [PDF]

Bioinform Adv
Montalvão RW, Bray S, Veríssimo-Alves M, Cubero E, Grüning B, Pinheiro VB.   +5 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Joint Service Chain Orchestration and Computation Offloading via GNN-Based QMIX in Industrial IoT. [PDF]

Sensors (Basel)
Huang X, Tian B.
europepmc   +1 more source