Results 51 to 60 of about 5,296,727 (239)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Service Dog Impact Evaluation

, 2020
Service Dog Impact Evaluation. An independent, third-party evaluator examine the impact that Pawsitivity service dogs have on the people they serve, and using a rigorous qualitative evaluation method, describe the results. Conducted by Aurora Consulting,
Tom COLEMAN (8479998)
core   +1 more source

Professiograph of activity of cynological specialists of the MIA of Russia as a critical element of quality training of a specialist

Вестник Мининского университета
Introduction. The article reveals the importance of the canine units of the Russian Ministry of Internal Affairs in ensuring the country's security.
T. P. Skripkina, E. A. Kusakina
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Protective Factors for Suicide: A Multi-Tiered Veteran-Driven Community Engagement Project

Journal of Veterans Studies, 2019
Objective: It is well known that veterans experience elevated rates of mental illness and suicide as compared to the general population. However, at-risk veterans often do not utilize traditional mental-health services due to inaccessibility, cost, and ...
Cheryl A. Krause-Parello, Michael J. Rice, Sarah Sarni, Carl LoFaro, Kosuke Niitsu, Michelle McHenry-Edrington, Kelly Blanchard   +6 more
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

[News Clip: Dog]

, 1958
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about a Dallas service station dog named Spot being considered for the National Hero Dog award for thwarting two ...
WBAP-TV (Television station : Fort Worth, Tex.)
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Minnesota 4-H Dog Parts Crossword Puzzle [PDF]

, 1982
This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.University of Minnesota Agricultural Extension Service ...
University of Minnesota Agricultural Extension Service
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