Results 41 to 50 of about 5,348,294 (244)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

General and Veterinary Care of Service Dogs and How Service Dogs Benefit Their Handlers

, 2020
Service or assistance dogs are protected under the Americans with Disabilities Act and provide handlers with disabilities assistance by performing specific trained tasks.
Eggert, Hannah
core  

Dogs as sources and sentinels of parasites in humans and wildlife, northern Canada [PDF]

, 2008
A minimum of 11 genera of parasites, including 7 known or suspected to cause zoonoses, were detected in dogs in 2 northern Canadian communities. Dogs in remote settlements receive minimal veterinary care and may serve as sources and sentinels for ...
Brett T. Elkin, Douglas P. Whiteside, Thompson, R.C.A., Salb, Amanda L., Barkema, H.W., Black, S.R., Whiteside, D.P., R.C. Andrew Thompson, Kutz, S.J., Amanda L. Salb, Sandra R. Black, J.P. Dubey, Susan J. Kutz, Elkin, B.T., Herman W. Barkema, Dubey, J.P.   +15 more
core   +1 more source

Socio‐economic evaluation of human–dog coexistence: A 40,000 years history

Veterinary Medicine and Science
The human–animal relationship and its benefits have been a popular issue in recent decades. This study focuses on the dog as a paradigmatic example of this complex bond.
Mohammad Fallahi, Ali Akbar Masoudi, Rasoul Vaez Torshizi, Ali Maghsoudi   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Prevalence of Leishmania spp. infection in domestic dogs in Chapare, Bolivia.

, 2011
Data on Leishmania spp. infection in dogs in Bolivia is scarce. Dogs from an area where 90% of human cutaneous leishmaniasis (CL) cases are due to Leishmania (Viannia) braziliensis were screened for Leishmania infection using established enzyme-linked ...
Reithinger, Richard, Mary Cruz Torrico, Parrado, Rudy, Garcia, Ana Lineth, Delgado, Raúl, Richard Reithinger, Torrico, Mary Cruz, Ana Lineth Garcia, Rojas, Ernesto, Rudy Parrado, Ernesto Rojas, Raúl Delgado   +11 more
core   +1 more source

Domestic dogs use contextual information and tone of voice when following a human pointing gesture [PDF]

, 2011
Domestic dogs are skillful at using the human pointing gesture. In this study we investigated whether dogs take contextual information into account when following pointing gestures, specifically, whether they follow human pointing gestures more readily ...
Grassmann, Susanne, Linda Scheider, Tomasello Michael, Tomasello, M., Juliane Kaminski, Tomasello, M. ; https://orcid.org/, Scheider, Linda, Scheider Linda, Tomasello, Michael, Scheider, L., Kaminski, J. ; https://orcid.org/, Michael Tomasello, Grassmann Susanne, Kaminski Juliane, Grassmann, S. ; https://orcid.org/, Kaminski, Juliane, Susanne Grassmann   +16 more
core   +1 more source

Case Distribution, Sources, and Breeds of Dogs Presenting to a Veterinary Behavior Clinic in the United States from 1997 to 2017

Animals, 2022
The purpose of this retrospective case study was to evaluate trends over time in case distribution, sources, and breeds of dogs presenting to the behavioral medicine service at a veterinary college referral hospital in the United States.
Katherine H. Anderson, Yufan Yao, Pamela J. Perry, Julia D. Albright, Katherine A. Houpt   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Service Dogs and Their Impact on PTSD

, 2016
Many individuals seek comfort in dogs, but not many realize the benefits that can be received from a “man’s best friend”. Dogs can be comforting, but can also be trained to acquire the special skills needed to help others. Service dogs can benefit a wide
Hernandez, Ashley M, Stevens, Christina
core   +1 more source