Results 51 to 60 of about 319,874 (307)

Dynamic capabilities for service innovation in service systems

open access: yes, 2015
© Springer-Verlag London 2015. One of the principal drivers of productivity growth is innovation, which includes not only technological but nontechnological innovations.
Agrawal, Renu   +5 more
core   +2 more sources

SERVICE BUSINESS MODEL AND SERVICE INNOVATIVENESS [PDF]

open access: yesInternational Journal of Innovation Management, 2014
Service innovativeness has been hailed as a key success factor in being able to differentiate a new service from its competing offerings. In spite of a number of literatures suggesting the impact that a service business model can have on service innovativeness, no comprehensive and empirical study has examined the relationship between the distinctive ...
COLIN C. J. CHENG   +2 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Service Innovation and Performance in Mexican Service SMEs [PDF]

open access: yes, 2017
This empirical research investigates the influence of service innovation on the performance of service SMEs, especially within the context of a country with an emerging economy as it is the case of Mexico.
Vikas Kumar   +8 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

DO THE REGIONS OF ROMANIA HAVE POTENTIAL FOR SERVICE INNOVATION? THE CASE OF THE REGION OF BUCHAREST-ILFOV [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
The paper is focused on conducting an assessment on one particular region of Romania, namely the region of Bucharest-Ilfov, in relation to service innovation.
IOSIF ALINA-ELENA
doaj  

Dukcapil Service Innovation in Improving the Quality of Service in the Lebong District

open access: yesJurnal Public Policy, 2022
This article aims to describe and provide an overview of the application-based innovation of the Lebong Dukcapil Service in the process of making population administration documents in the Lebong Regency to improve the quality of quality public services.
Novliza Eka Patrisia   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Service innovation: A review of the literature

open access: yes, 2015
© Springer-Verlag London 2015. Services are fast overtaking manufacturing to form a dominant proportion of the world economy. Service innovation is increasingly seen as a vector of sustainable growth and competitive advantage at the firm-, industry- and ...
Moira Scerri   +3 more
core   +1 more source

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