Results 71 to 80 of about 13,114,410 (297)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Language support for service-level agreements for application-service provision [PDF]
, 2007 My thesis is that practical language support can be provided for Service-Level Agreements (SLAs) for Application-Service Provision (ASP), which is better than that provided by pre-existing languages in that: it provides greater assistance in expressing
Skene, J.
core
IEEE AccessEmerging applications such as extreme virtual reality, enterprise access, 5G front-haul / back-haul, and future 6G immersive services demand exceptional bandwidth and low latency.
Sukriti Garg, Noemi Merayo
doaj +1 more source
Flexibility-Based Energy and Demand Management in Data Centers: A Case Study for Cloud Computing
Energies, 2019 The power demand (kW) and energy consumption (kWh) of data centers were augmented drastically due to the increased communication and computation needs of IT services. Leveraging demand and energy management within data centers is a necessity.
Robert Basmadjian
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Dynamic service provisioning using GRIA SLAs
, 2007 Service Level Agreements (SLA) include quality of service (QoS) constraints and bounds that have to be honoured by the service provider. To maximise the Service Provider revenue while satisfying the QoS requirements of the agreed SLAs it is important to ...
Boniface, Mike J. +3 more
core +1 more source
Personal service agreements-OPM's standards
, 2006 Began in 2002?; Title from home page last modified 7/18/2007 (viewed Sept. 12, 2007).; Mandated by Public Act 93-336, an Act Implementing the Recommendations of the Legislative Program Review and Investigations Committee Concerning Personal Service ...
core +2 more sources