Results 91 to 100 of about 13,113,594 (311)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

The Health Service Executive Performance and Accountability Framework 2017

, 2016
1.1 What is the Performance and Accountability Framework? The Performance and Accountability Framework sets out the means by which the HSE and in particular the National Divisions, Hospital Groups, Community Healthcare Organisations (CHOs), the National ...
Health Service Executive (HSE)
core  

Harmonic heterostructured pure Ti fabricated by laser powder bed fusion for excellent wear resistance via strength-plasticity synergy

Opto-Electronic Advances
Titanium (Ti) is a promising candidate for biomedical implants due to lightweight, superior corrosion resistance and biocompatibility. Nevertheless, pure Ti is confronted with poor wear resistance which poses a profound bottleneck for orthopedic implant ...
Desheng Li, Huanrong Xie, Chengde Gao, Huan Jiang, Liyuan Wang, Cijun Shuai   +5 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Welding-induced corrosion and protective measures for clad rebars in neutral chloride environments

Scientific Reports
Corrosion-resistant steel plays a vital role in marine steel structures. This study developed an SS304/HRB400 stainless-steel-clad rebar for application in a cross-sea bridge in Zhejiang Province.
Zecheng Zhuang, Weiping Lu, Lei Zeng, Jianping Tan, Xuehai Qian, Zhen Li, Wei Jiang, Yong Xiang   +7 more
doaj   +1 more source

Multi-scale synergistic reinforcement and performance control of PVA/fiber binary system in preparation of fused silica via gel method

Journal of Materials Research and Technology
Gel casting faces challenges like low strength, non-uniformity and long cycles in making large fused silica parts. To address these issues, this study addresses challenges by introducing a composite reinforcement system of silica fibers and polyvinyl ...
Haikuan Chen, Xiaoyan Sun, Zhouwei He, Youwang Hu, Ji'an Duan   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Acknowledgement to reviewers

Africa’s Public Service Delivery & Performance Review
No abstract available.
Editorial Office
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The Health Service Executive Performance and Accountability Framework 2020

, 2020
Developing and implementing an effective performance management and accountability system in the HSE is a priority for our Board. The Board has established a number of committees to assist and advise the Board in relation to the performance of its ...
Health Service Executive
core